Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50033176
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340908BDBM50340908((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340911BDBM50340911((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340902BDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK2 in presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340902BDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340893BDBM50340893((4-amino-2-(3-aminophenylamino)thiazol-5-yl)(3-flu...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340896BDBM50340896((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340897BDBM50340897((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340894BDBM50340894((4-amino-2-(3-(methylamino)phenylamino)thiazol-5-y...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340902BDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of GSK3-beta in presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340913BDBM50340913((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340903BDBM50340903((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-fluo...)
Affinity DataIC50: 62nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340895BDBM50340895((4-amino-2-(4-(dimethylamino)phenylamino)thiazol-5...)
Affinity DataIC50: 68nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340899BDBM50340899((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 80nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340884BDBM50340884((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340906BDBM50340906((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(3-nitr...)
Affinity DataIC50: 130nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340887BDBM50340887((4-amino-2-(6-(trifluoromethyl)pyridin-3-ylamino)t...)
Affinity DataIC50: 160nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340914BDBM50340914((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50155426BDBM50155426(Xanthen-9-one, 1.0 | 1,3,5,8-Tetrahydroxy-xanthen-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 7533BDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 270nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340905BDBM50340905((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(phenyl...)
Affinity DataIC50: 341nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340910BDBM50340910((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340900BDBM50340900((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(3-meth...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340912BDBM50340912((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340907BDBM50340907((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-meth...)
Affinity DataIC50: 418nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340891BDBM50340891((4-amino-2-(piperidin-3-ylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340882BDBM50340882((4-amino-2-(pyridin-4-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340889BDBM50340889((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340888BDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 750nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340883BDBM50340883((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340901BDBM50340901((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340898BDBM50340898((4-amino-2-(pyridin-2-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340885BDBM50340885((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(pyridi...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340888BDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340909BDBM50340909((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(4-meth...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340890BDBM50340890((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-me...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340904BDBM50340904((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(4-fluo...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMicrotubule-associated protein tau(Rat)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340902BDBM50340902((4-amino-2-(pyridin-3-ylamino)thiazol-5-yl)(2-fluo...)
Affinity DataEC50:  5.50E+3nMAssay Description:Inhibition of tau protein phosphorylation at Ser396 in rat brain cells at 0.5 to 50 uM after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340892BDBM50340892((4-amino-2-(piperidin-4-ylamino)thiazol-5-yl)(3-fl...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340886BDBM50340886((2-fluorophenyl)(4-(methylamino)-2-(pyridin-3-ylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed