Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50039397
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 2.13nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 2.71nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 2.73nMAssay Description:inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 2.87nMAssay Description:inhibition of RAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.87nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50358043(GW-5074 | CHEMBL1794051)
Affinity DataIC50: 2.87nMAssay Description:inhibition of RAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 4.13nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 4.79nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 9.42nMAssay Description:inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 18.2nMAssay Description:inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 21.5nMAssay Description:inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338874(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-...)
Affinity DataIC50: 22.4nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 51.6nMAssay Description:inhibition of IGF-1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 101nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 107nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 167nMAssay Description:inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 194nMAssay Description:Inhibition of c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338875(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 277nMAssay Description:inhibition of RONMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 1.59E+3nMAssay Description:inhibition of JNK1a1 at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM12915(CHEMBL98350 | 2-(morpholin-4-yl)-8-phenyl-4H-chrom...)
Affinity DataIC50: 3.02E+3nMAssay Description:inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 3.02E+3nMAssay Description:inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338876(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-...)
Affinity DataIC50: 8.32E+3nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed