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Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50033323
TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343301(2-((4-(4-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343305(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343317(1-methyl-2-(((1R,5S)-3-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi:  355nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343308(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  404nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343295(2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-m...)
Affinity DataKi:  426nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  561nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343316(CHEMBL1774224 | cis-1-methyl-2-(((2R,4R)-2-methyl-...)
Affinity DataKi:  589nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343309(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  671nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343314(2-((4-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperid...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343313(2-((4-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  1.78E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343312(2-((4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperid...)
Affinity DataKi:  2.43E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343318((S)-2-((3,3-dimethyl-4-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343320(CHEMBL1774228 | cis-1-methyl-2-(((3S,4S)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343327(CHEMBL1774235 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >4.68E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343325(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343323(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343315(CHEMBL1774223 | trans-1-((1-Methyl-1H-imidazo[4,5-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343316(CHEMBL1774224 | cis-1-methyl-2-(((2R,4R)-2-methyl-...)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343317(1-methyl-2-(((1R,5S)-3-(4-(trifluoromethyl)phenyl)...)
Affinity DataEC50:  184nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343318((S)-2-((3,3-dimethyl-4-(4-(trifluoromethyl)phenyl)...)
Affinity DataEC50:  745nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataEC50:  111nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataEC50:  111nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343320(CHEMBL1774228 | cis-1-methyl-2-(((3S,4S)-3-methyl-...)
Affinity DataEC50: >1.99E+3nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343322(CHEMBL1774230 | cis-2-(((3S,4S)-4-(4-chloro-2-fluo...)
Affinity DataEC50: >1.81E+3nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343323(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Affinity DataEC50:  22nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343324(CHEMBL1774232 | cis-2-(((3S,4S)-4-(2-methoxy-4-(tr...)
Affinity DataEC50:  787nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343325(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  9nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343326(CHEMBL1774234 | cis-2-(((3S,4S)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  993nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343327(CHEMBL1774235 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343328(CHEMBL1774236 | cis-2-(((3S,4S)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  818nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343308(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  43nMAssay Description:Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343323(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343325(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  3nMAssay Description:Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343327(CHEMBL1774235 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataEC50:  31nMAssay Description:Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343314(2-((4-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperid...)
Affinity DataEC50:  25nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343313(2-((4-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  25.1nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343312(2-((4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperid...)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343311(3-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  285nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343310(3-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  196nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343309(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  168nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343308(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  48nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  109nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  78nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343305(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Affinity DataEC50:  7.60nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343304(CHEMBL1774106 | N-Methyl-3-(1-((1-methyl-1H-benzo[...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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