Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50022574
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.0510nMAssay Description:Antagonist activity at GFP-tagged human TRPA1 transfected in HEK293F cells assessed as reduction in AITC-induced inward current at -60 mV holding pot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.0670nMAssay Description:Antagonist activity at recombinant human TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.101nMAssay Description:Antagonist activity at GFP-tagged rat TRPA1 transfected in HEK293F cells assessed as reduction in AITC-induced inward current at -60 mV holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.289nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.296nMAssay Description:Antagonist activity at mouse TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652931(CHEMBL5687035)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at TRPA1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at TRPA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at recombinant human TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652931(CHEMBL5687035)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at recombinant human TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50652931(CHEMBL5687035)
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase in intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50321851(CHEMBL1173240 | US8796328, D | (R)-8-{5-[3-Methyl-...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293F cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ level by FLIPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPV4 expressed in HEK293F cells assessed as inhibition of mOsmo-induced increase in intracellular Ca2+ level by FLIPR-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at endogenous TRPV3 in human epithelial cells assessed as inhibition of 2APB-induced increase in intracellular Ca2+ level by FLIP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPV2 expressed in HEK293F cells assessed as inhibition of 2APB-induced increase in intracellular Ca2+ level by FLIPR-base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293F cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed