Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50033136
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340122(N4-(naphthalen-2-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340126(N2-(3-methoxy-4-morpholinophenyl)-N4-(quinolin-3-y...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 3nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340128(N4-(quinolin-6-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340144(N2-(3-methoxy-4-(3-(piperidin-1-yl)propoxy)phenyl)...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(N4-(isoquinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)p...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340126(N2-(3-methoxy-4-morpholinophenyl)-N4-(quinolin-3-y...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340120(N2-(naphthalen-2-yl)-N4-(3,4,5-trimethoxyphenyl)-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(N4-(isoquinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)p...)
Affinity DataIC50: 14nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340135(N2-(3,4-dimethoxyphenyl)-N4-(quinolin-3-yl)pyrimid...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 19nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(N2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N4-(quino...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340136(N2-(3,5-dimethoxyphenyl)-N4-(quinolin-3-yl)pyrimid...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340142(N2-(4-morpholinophenyl)-N4-(quinolin-3-yl)pyrimidi...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(N2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N4-(quino...)
Affinity DataIC50: 24nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340118(N4-(3-(trifluoromethoxy)phenyl)-N2-(3,4,5-trimetho...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340131(N4-(1H-indazol-5-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340141(N2-(3-chloro-4-methoxyphenyl)-N4-(quinolin-3-yl)py...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340144(N2-(3-methoxy-4-(3-(piperidin-1-yl)propoxy)phenyl)...)
Affinity DataIC50: 36nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340128(N4-(quinolin-6-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 37nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340138(N2-(3-methoxyphenyl)-N4-(quinolin-3-yl)pyrimidine-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340140(N2-(3-chlorophenyl)-N4-(quinolin-3-yl)pyrimidine-2...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340119(N2-(quinolin-3-yl)-N4-(3,4,5-trimethoxyphenyl)-1,3...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340123(N4-(2-methylquinolin-3-yl)-N2-(3,4,5-trimethoxyphe...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340137(N2-(4-methoxyphenyl)-N4-(quinolin-3-yl)pyrimidine-...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340129(N4-(quinoxalin-6-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(N2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N4-(quino...)
Affinity DataIC50: 81nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340122(N4-(naphthalen-2-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 88nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 94nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340130(N4-(1H-indazol-6-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 103nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340133(N4-(3,3-dimethylindolin-6-yl)-N2-(3,4,5-trimethoxy...)
Affinity DataIC50: 123nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340119(N2-(quinolin-3-yl)-N4-(3,4,5-trimethoxyphenyl)-1,3...)
Affinity DataIC50: 175nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340142(N2-(4-morpholinophenyl)-N4-(quinolin-3-yl)pyrimidi...)
Affinity DataIC50: 177nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340139(N4-(quinolin-3-yl)-N2-(3-(trifluoromethoxy)phenyl)...)
Affinity DataIC50: 198nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340132(N4-(1H-benzo[d]imidazol-6-yl)-N2-(3,4,5-trimethoxy...)
Affinity DataIC50: 201nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340134(N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrim...)
Affinity DataIC50: 251nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340141(N2-(3-chloro-4-methoxyphenyl)-N4-(quinolin-3-yl)py...)
Affinity DataIC50: 356nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340120(N2-(naphthalen-2-yl)-N4-(3,4,5-trimethoxyphenyl)-1...)
Affinity DataIC50: 409nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340123(N4-(2-methylquinolin-3-yl)-N2-(3,4,5-trimethoxyphe...)
Affinity DataIC50: 420nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340129(N4-(quinoxalin-6-yl)-N2-(3,4,5-trimethoxyphenyl)py...)
Affinity DataIC50: 448nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340133(N4-(3,3-dimethylindolin-6-yl)-N2-(3,4,5-trimethoxy...)
Affinity DataIC50: 490nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340135(N2-(3,4-dimethoxyphenyl)-N4-(quinolin-3-yl)pyrimid...)
Affinity DataIC50: 507nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 711nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340124(N4-methyl-N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyp...)
Affinity DataIC50: 725nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 746nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 853nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340125(4-(quinolin-3-yloxy)-N-(3,4,5-trimethoxyphenyl)pyr...)
Affinity DataIC50: 933nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340138(N2-(3-methoxyphenyl)-N4-(quinolin-3-yl)pyrimidine-...)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340143(N2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N4-(quino...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
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