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Found 14 Enz. Inhib. hit(s) with all data for entry = 50004536
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330327((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Affinity DataIC50:  680nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483850(CHEMBL1774147)
Affinity DataIC50:  680nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483849(CHEMBL1774153)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483851(CHEMBL1774264)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483850(CHEMBL1774147)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330327((R)-7-(3-(2-aminopropan-2-yl)pyrrolidin-1-yl)-9-cy...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178917((S,Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidi...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483851(CHEMBL1774264)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483849(CHEMBL1774153)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178917((S,Z)-7-(3-(aminomethyl)-4-(methoxyimino)pyrrolidi...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase Ser84Leu mutant assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed