Compile Data Set for Download or QSAR
maximum 50k data
Found 75 Enz. Inhib. hit(s) with all data for entry = 50033252
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342169(CHEMBL1766170 | rac-1-(4'-Fluoro[1,1'-biphenyl]-3-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342168(CHEMBL1765101 | rac-1-(1H-Imidazol-4-yl)-1-(4'-met...)
Affinity DataIC50:  10nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342186((S)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342167(CHEMBL1766169 | rac-1-[1,1'-biphenyl]-3-yl-1-(1H-i...)
Affinity DataIC50:  15nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342175(CHEMBL1766176 | rac-N-{4-[1-Hydroxy-1-(1H-imidazol...)
Affinity DataIC50:  17nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342167(CHEMBL1766169 | rac-1-[1,1'-biphenyl]-3-yl-1-(1H-i...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342170(CHEMBL1766171 | rac-1-(4'-Chloro[1,1'-biphenyl]-3-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342190((S)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)propyl)bi...)
Affinity DataIC50:  19nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342169(CHEMBL1766170 | rac-1-(4'-Fluoro[1,1'-biphenyl]-3-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342179(CHEMBL1766180 | rac-N-{4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342190((S)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)propyl)bi...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342179(CHEMBL1766180 | rac-N-{4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  24nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342175(CHEMBL1766176 | rac-N-{4-[1-Hydroxy-1-(1H-imidazol...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342176(CHEMBL1766177 | rac-N-{4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  24nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342183(CHEMBL1766184 | rac-N-[4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342188((S)-N-(6-(4-(1-hydroxy-1-(1H-imidazol-4-yl)-2-meth...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342186((S)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342173(CHEMBL1766174 | rac-1-(4'-Fluoro[1,1'-biphenyl]-4-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342174(CHEMBL1766175 | rac-1-(4'-Chloro[1,1'-biphenyl]-4-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342173(CHEMBL1766174 | rac-1-(4'-Fluoro[1,1'-biphenyl]-4-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342174(CHEMBL1766175 | rac-1-(4'-Chloro[1,1'-biphenyl]-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342188((S)-N-(6-(4-(1-hydroxy-1-(1H-imidazol-4-yl)-2-meth...)
Affinity DataIC50:  33nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342171(CHEMBL1766172 | rac-1-[1,1'-Biphenyl]-4-yl-1-(1H-i...)
Affinity DataIC50:  33nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342171(CHEMBL1766172 | rac-1-[1,1'-Biphenyl]-4-yl-1-(1H-i...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342181(CHEMBL1766182 | rac-N-{6-(4-[1-Hydroxy-1-(1H-imida...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342182(CHEMBL1766183 | rac-N-[4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342183(CHEMBL1766184 | rac-N-[4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342177(CHEMBL1766178 | rac-4'-[1-Hydroxy1-(1H-imidazol-4-...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342184(CHEMBL1766185 | rac-N-[4'-[Cyclopropyl(hydroxy)-1H...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342170(CHEMBL1766171 | rac-1-(4'-Chloro[1,1'-biphenyl]-3-...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342177(CHEMBL1766178 | rac-4'-[1-Hydroxy1-(1H-imidazol-4-...)
Affinity DataIC50:  49nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342181(CHEMBL1766182 | rac-N-{6-(4-[1-Hydroxy-1-(1H-imida...)
Affinity DataIC50:  53nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342172(CHEMBL1766173 | rac-1-(1H-Imidazol-4-yl)-1-(4'-met...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342182(CHEMBL1766183 | rac-N-[4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  62nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342178(CHEMBL1766179 | rac-4'-[1-Hydroxy-1-(1H-imidazol-4...)
Affinity DataIC50:  71nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342185(CHEMBL1766186 | rac-N-[4'-[1-Hydroxy(1H-imidazol-4...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342184(CHEMBL1766185 | rac-N-[4'-[Cyclopropyl(hydroxy)-1H...)
Affinity DataIC50:  81nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342189((R)-N-(6-(4-(1-hydroxy-1-(1H-imidazol-4-yl)-2-meth...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342172(CHEMBL1766173 | rac-1-(1H-Imidazol-4-yl)-1-(4'-met...)
Affinity DataIC50:  120nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342176(CHEMBL1766177 | rac-N-{4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342168(CHEMBL1765101 | rac-1-(1H-Imidazol-4-yl)-1-(4'-met...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342180(CHEMBL1766181 | rac-1-(1H-Imidazol-4-yl)-2-methyl-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342178(CHEMBL1766179 | rac-4'-[1-Hydroxy-1-(1H-imidazol-4...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342180(CHEMBL1766181 | rac-1-(1H-Imidazol-4-yl)-2-methyl-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342191((R)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)propyl)bi...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342185(CHEMBL1766186 | rac-N-[4'-[1-Hydroxy(1H-imidazol-4...)
Affinity DataIC50:  320nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342187((R)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human 17,20 lyase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342191((R)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)propyl)bi...)
Affinity DataIC50:  450nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342187((R)-N-(4'-(1-hydroxy-1-(1H-imidazol-4-yl)-2-methyl...)
Affinity DataIC50:  770nMAssay Description:Inhibition of 17,20 lyase activity in Sprague-Dawley rat testicular microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342176(CHEMBL1766177 | rac-N-{4'-[1-Hydroxy-1-(1H-imidazo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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