Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with all data for entry = 50039405
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 28nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 33nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 34nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 34nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340503(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 35nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340500(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Affinity DataIC50: 43nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340501(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Affinity DataIC50: 47nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 55nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340503(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340503(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340514(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Affinity DataIC50: 117nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 145nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340501(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Affinity DataIC50: 154nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340501(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)
Affinity DataIC50: 154nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(N-(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethy...)
Affinity DataIC50: 175nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50: 180nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340500(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Affinity DataIC50: 202nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340500(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)
Affinity DataIC50: 202nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340514(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Affinity DataIC50: 264nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340514(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Affinity DataIC50: 264nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of insulin receptor kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340516((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 410nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340499(1-((2-(isopropylamino)pyridin-4-yl)methyl)-5,5-dim...)
Affinity DataIC50: 453nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340520(5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 460nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 500nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340498(1-((2-ethylpyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Affinity DataIC50: 574nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 600nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340484((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340497(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylth...)
Affinity DataIC50: 703nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340496(tert-butyl 4-((5,5-dimethyl-2,4-dioxo-3-(4-(triflu...)
Affinity DataIC50: 784nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340495(1-((2-chloropyridin-4-yl)methyl)-5,5-dimethyl-3-(4...)
Affinity DataIC50: 995nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340494(1-((2-(benzylamino)pyridin-4-yl)methyl)-5,5-dimeth...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340493(5,5-dimethyl-1-((2-(phenylamino)pyridin-4-yl)methy...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340492(1-((2-(4-methoxybenzylamino)pyridin-4-yl)methyl)-5...)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340491(1-((2-(cyclohexylamino)pyridin-4-yl)methyl)-5,5-di...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340504((S)-5-methyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340490(1-((2-ethoxypyridin-4-yl)methyl)-5,5-dimethyl-3-(4...)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340515((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(triflu...)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
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