Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50033259
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human URAT1 expressed in human MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342286((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-methoxyben...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342289((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-hydroxyben...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342292((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-methoxyben...)
Affinity DataIC50: 111nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 138nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342294((6-Bromo-2-ethyl-7-hydroxybenzofuran-4-yl)(3,5-dib...)
Affinity DataIC50: 177nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342287((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-hydroxyben...)
Affinity DataIC50: 189nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342279((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human URAT1 expressed in human MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342291((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-hydroxyben...)
Affinity DataIC50: 287nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342288((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-methoxyben...)
Affinity DataIC50: 358nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342296((5,7-Dibromo-2-ethyl-6-hydroxybenzofuran-3-yl)(4-m...)
Affinity DataIC50: 667nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342297((6-Bromo-2-ethyl-7-hydroxybenzofuran-4-yl)(4-metho...)
Affinity DataIC50: 772nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342283((2-Ethyl-6-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342290((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-5-methoxyben...)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342293((5-Bromo-2-ethyl-6-methoxybenzofuran-3-yl)(3,5-dib...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342277((2-Ethyl-5-methoxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342276((2-Ethyl-5-hydroxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342278((2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342282((2-Ethyl-6-methoxybenzofuran-3-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 3.92E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342285((2-Ethyl-7-hydroxybenzofuran-4-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342280((2-Ethyl-5-methoxybenzofuran-4-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342284((2-Ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342295((4,6-Dibromo-2-ethyl-5-hydroxybenzofuran-3-yl)(4-m...)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50342281((2-Ethyl-5-methoxybenzofuran-7-yl)(4-hydroxyphenyl...)
Affinity DataIC50: 3.37E+4nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50206509(CHEMBL897 | 4-Dipropylsulfamoyl-benzoic acid(probe...)
Affinity DataIC50: 8.64E+4nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed