Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50033406
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344669BDBM50344669(6,8-dichloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Rat)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344685BDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20880BDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344680BDBM50344680(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Rat)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344681BDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344679BDBM50344679(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344685BDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344678BDBM50344678(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344675BDBM50344675(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3-tri...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344676BDBM50344676(6-chloro-8-nitro-4-((5-(5-(trifluoromethyl)pyridin...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344666BDBM50344666(4-((5-(benzyloxymethyl)-4-(3,3,3-trifluoropropyl)-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344683BDBM50344683(6,8-dimethyl-4-((5-((1R,2R)-2-phenylcyclopropyl)-4...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344670BDBM50344670(6,8-dichloro-4-((5-(2-methylthiazol-4-yl)-4-(3,3,3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344684BDBM50344684((R)-6,8-dimethyl-4-((4-propyl-5-(1,2,3,4-tetrahydr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340013BDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344671BDBM50344671(rac-6,8-dichloro-4-((5-(2-phenylcyclopropyl)-4-(3,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344681BDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344668BDBM50344668(6,8-dichloro-4-((5-(pyridin-2-yl)-4-(3,3,3-trifluo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344673BDBM50344673(6,8-dichloro-4-((5-(2,3-dihydro-1H-inden-2-yl)-4-(...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344672BDBM50344672(rac-6,8-dichloro-4-((5-(1,2,3,4-tetrahydronaphthal...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344690BDBM50344690(N-(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tri...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344691BDBM50344691(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344667BDBM50344667(6,8-dichloro-4-((5-(4-chlorophenyl)-4-(3,3,3-trifl...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344688BDBM50344688(8-amino-6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344674BDBM50344674(6-chloro-8-nitro-4-((5-(pyridin-2-yl)-4-(3,3,3-tri...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344686BDBM50344686(methyl 6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344692BDBM50344692(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344665BDBM50344665(6,8-dichloro-4-((5-((4-chlorophenoxy)methyl)-4-(3,...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344694BDBM50344694(rac-6,8-dichloro-4-((5-(2-phenylpropyl)-4-(3,3,3-t...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344677BDBM50344677(6-chloro-3-oxo-4-((5-(pyridin-2-yl)-4-(3,3,3-trifl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344695BDBM50344695(6,8-dichloro-4-((5-(2-methyl-2-phenylpropyl)-4-(3,...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344693BDBM50344693(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50: 660nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344682BDBM50344682(6-chloro-4-((5-(3-methylpyridin-2-yl)-4-propyl-4H-...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50340013BDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344689BDBM50344689(N-(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tri...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344687BDBM50344687(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344681BDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50344685BDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed