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Found 107 Enz. Inhib. hit(s) with all data for entry = 50040556
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)
Affinity DataIC50:  80nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  90nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396066(CHEMBL1819479)
Affinity DataIC50:  200nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396061(CHEMBL1173121)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351425(CHEMBL1819478)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322464(2-(4,6-diphenethoxypyrimidin-2-ylthio)octanoic aci...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396065(CHEMBL1819480)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322467(2-(4,6-Bis(4-methylphenethoxy)pyrimidin-2-ylthio)-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396062(CHEMBL1171652)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322468(2-(4,6-Bis(4-(trifluoromethoxy)phenethoxy)pyrimidi...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322461(2-(4,6-Bis(4-(trifluoromethyl)phenethoxy)pyrimidin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351420(CHEMBL1817687)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50273683(2-(4,6-Diphenethoxypyrimidin-2-ylthio)hexanoic aci...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396060(CHEMBL1171832)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351418(CHEMBL1819391)
Affinity DataIC50:  700nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322466(2-(4,6-Bis(4-phenylbutoxy)pyrimidin-2-ylthio)hexan...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322469(2-(4,6-Bis(4-cyanophenethoxy)pyrimidin-2-ylthio)he...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396067(CHEMBL1819398)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396068(CHEMBL2170363)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396064(CHEMBL1171851)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322460(2-(4,6-Bis(2-cyclohexylethoxy)pyrimidin-2-ylthio)h...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351419(CHEMBL1819392)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351424(CHEMBL1819397)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351423(CHEMBL1819396)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322466(2-(4,6-Bis(4-phenylbutoxy)pyrimidin-2-ylthio)hexan...)
Affinity DataIC50:  900nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322467(2-(4,6-Bis(4-methylphenethoxy)pyrimidin-2-ylthio)-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322465(2-(4,6-Bis(3-phenylpropoxy)pyrimidin-2-ylthio)hexa...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396068(CHEMBL2170363)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322472(2-(4,6-Bis(isopentyloxy)pyrimidin-2-ylthio)hexanoi...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50273683(2-(4,6-Diphenethoxypyrimidin-2-ylthio)hexanoic aci...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396064(CHEMBL1171851)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322471(2-(4,6-Bis(2-cyclopropylethoxy)pyrimidin-2-ylthio)...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351424(CHEMBL1819397)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396063(CHEMBL1172222)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322461(2-(4,6-Bis(4-(trifluoromethyl)phenethoxy)pyrimidin...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322464(2-(4,6-diphenethoxypyrimidin-2-ylthio)octanoic aci...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351421(CHEMBL1819393)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322461(2-(4,6-Bis(4-(trifluoromethyl)phenethoxy)pyrimidin...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322465(2-(4,6-Bis(3-phenylpropoxy)pyrimidin-2-ylthio)hexa...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322466(2-(4,6-Bis(4-phenylbutoxy)pyrimidin-2-ylthio)hexan...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50396059(CHEMBL1171833)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322460(2-(4,6-Bis(2-cyclohexylethoxy)pyrimidin-2-ylthio)h...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351417(CHEMBL1819390)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351423(CHEMBL1819396)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351422(CHEMBL1819394)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322465(2-(4,6-Bis(3-phenylpropoxy)pyrimidin-2-ylthio)hexa...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50322462(2-(4,6-Diphenethoxypyrimidin-2-ylthio)butanoic aci...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50351418(CHEMBL1819391)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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