Compile Data Set for Download or QSAR
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Found 40 Enz. Inhib. hit(s) with all data for entry = 50004547
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483944(CHEMBL1797105)
Affinity DataIC50:  40nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483943(CHEMBL1797102)
Affinity DataIC50:  50nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483955(CHEMBL1797103)
Affinity DataIC50:  50nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483946(CHEMBL1797111)
Affinity DataIC50:  50nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483942(CHEMBL1797100)
Affinity DataIC50:  50nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483940(CHEMBL1797097)
Affinity DataIC50:  63nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483956(CHEMBL1797099)
Affinity DataIC50:  63nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483954(CHEMBL1797110)
Affinity DataIC50:  63nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483951(CHEMBL1797108)
Affinity DataIC50:  63nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483941(CHEMBL1797098)
Affinity DataIC50:  79nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483942(CHEMBL1797100)
Affinity DataIC50:  79nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483947(CHEMBL1797112)
Affinity DataIC50:  100nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483939(CHEMBL1797095)
Affinity DataIC50:  100nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483946(CHEMBL1797111)
Affinity DataIC50:  100nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483943(CHEMBL1797102)
Affinity DataIC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483957(CHEMBL1797109)
Affinity DataIC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483955(CHEMBL1797103)
Affinity DataIC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483956(CHEMBL1797099)
Affinity DataIC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483949(CHEMBL1797101)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483954(CHEMBL1797110)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483944(CHEMBL1797105)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483949(CHEMBL1797101)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483953(CHEMBL1797104)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483941(CHEMBL1797098)
Affinity DataIC50:  158nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483945(CHEMBL1797107)
Affinity DataIC50:  200nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483951(CHEMBL1797108)
Affinity DataIC50:  200nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483940(CHEMBL1797097)
Affinity DataIC50:  200nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483938(CHEMBL1797094)
Affinity DataIC50:  316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483950(CHEMBL1797106)
Affinity DataIC50:  316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483953(CHEMBL1797104)
Affinity DataIC50:  316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483945(CHEMBL1797107)
Affinity DataIC50:  501nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483948(CHEMBL1797096)
Affinity DataIC50:  631nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483938(CHEMBL1797094)
Affinity DataIC50:  631nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483939(CHEMBL1797095)
Affinity DataIC50:  794nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483948(CHEMBL1797096)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483950(CHEMBL1797106)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483957(CHEMBL1797109)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483952(CHEMBL1797093)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 42 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483947(CHEMBL1797112)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50483952(CHEMBL1797093)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta 40 formation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed