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Found 37 Enz. Inhib. hit(s) with all data for entry = 50033813
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Washington University

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Washington University

Curated by ChEMBL
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351893(CHEMBL1825071)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351891(CHEMBL1821790)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Washington University

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351892(CHEMBL1821791)
Affinity DataIC50:  48.8nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351908(CHEMBL1821774)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351890(CHEMBL1821787)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351894(CHEMBL1821789)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351895(CHEMBL1821775)
Affinity DataIC50:  58.5nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351896(CHEMBL1821776)
Affinity DataIC50:  112nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351897(CHEMBL1821777)
Affinity DataIC50:  198nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351898(CHEMBL1821784)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351899(CHEMBL1821779)
Affinity DataIC50:  237nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351900(CHEMBL1821778)
Affinity DataIC50:  244nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351901(CHEMBL1821788)
Affinity DataIC50:  246nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351902(CHEMBL1821782)
Affinity DataIC50:  248nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351903(CHEMBL1821785)
Affinity DataIC50:  262nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351904(CHEMBL1821786)
Affinity DataIC50:  303nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351905(CHEMBL1821783)
Affinity DataIC50:  469nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351906(CHEMBL1821780)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351907(CHEMBL1821781)
Affinity DataIC50:  872nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  917nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351895(CHEMBL1821775)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351908(CHEMBL1821774)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351908(CHEMBL1821774)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351895(CHEMBL1821775)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351894(CHEMBL1821789)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351890(CHEMBL1821787)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351894(CHEMBL1821789)
Affinity DataIC50:  2.17E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351891(CHEMBL1821790)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351890(CHEMBL1821787)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351891(CHEMBL1821790)
Affinity DataIC50:  2.52E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351892(CHEMBL1821791)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50351892(CHEMBL1821791)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed