Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50033813
LigandChemical structure of BindingDB Monomer ID 31592BDBM31592(PF-2545920 | substituted pyrazole, 9 | US9138494, ...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 31596BDBM31596(substituted pyrazole, 13)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351893BDBM50351893(CHEMBL1825071)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 14754BDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50351891BDBM50351891(CHEMBL1821790)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 14754BDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351892BDBM50351892(CHEMBL1821791)
Affinity DataIC50: 48.8nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351908BDBM50351908(CHEMBL1821774)
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351890BDBM50351890(CHEMBL1821787)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351894BDBM50351894(CHEMBL1821789)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351895BDBM50351895(CHEMBL1821775)
Affinity DataIC50: 58.5nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351896BDBM50351896(CHEMBL1821776)
Affinity DataIC50: 112nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351897BDBM50351897(CHEMBL1821777)
Affinity DataIC50: 198nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351898BDBM50351898(CHEMBL1821784)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351899BDBM50351899(CHEMBL1821779)
Affinity DataIC50: 237nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351900BDBM50351900(CHEMBL1821778)
Affinity DataIC50: 244nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351901BDBM50351901(CHEMBL1821788)
Affinity DataIC50: 246nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351902BDBM50351902(CHEMBL1821782)
Affinity DataIC50: 248nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351903BDBM50351903(CHEMBL1821785)
Affinity DataIC50: 262nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351904BDBM50351904(CHEMBL1821786)
Affinity DataIC50: 303nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351905BDBM50351905(CHEMBL1821783)
Affinity DataIC50: 469nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351906BDBM50351906(CHEMBL1821780)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50351907BDBM50351907(CHEMBL1821781)
Affinity DataIC50: 872nMAssay Description:Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14754BDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 917nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14754BDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351895BDBM50351895(CHEMBL1821775)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351908BDBM50351908(CHEMBL1821774)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351908BDBM50351908(CHEMBL1821774)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351895BDBM50351895(CHEMBL1821775)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351894BDBM50351894(CHEMBL1821789)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351890BDBM50351890(CHEMBL1821787)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351894BDBM50351894(CHEMBL1821789)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351891BDBM50351891(CHEMBL1821790)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351890BDBM50351890(CHEMBL1821787)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351891BDBM50351891(CHEMBL1821790)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351892BDBM50351892(CHEMBL1821791)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50351892BDBM50351892(CHEMBL1821791)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed