Compile Data Set for Download or QSAR
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Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50033853
TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of JNK1 using ATF2 substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataKi:  2nMAssay Description:Competitive inhibition of JNK1 using ATP by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352631(CHEMBL1822313)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of JNK1 using ATF2 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352631(CHEMBL1822313)
Affinity DataIC50:  0.900nMAssay Description:Displacement of biotin-RPKRPTTLNLF from GST tagged JNK1 using ATF2 substrate by dissociation enhanced lanthanide fluoro-immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataIC50:  18nMAssay Description:Inhibition of JNK1 using ATF2 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataIC50:  46nMAssay Description:Displacement of biotin-RPKRPTTLNLF from GST tagged JNK1 using ATF2 substrate by dissociation enhanced lanthanide fluoro-immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352630(CHEMBL1822310)
Affinity DataIC50:  1.00E+4nMAssay Description:Displacement of biotin-RPKRPTTLNLF from GST tagged JNK1 using ATF2 substrate by dissociation enhanced lanthanide fluoro-immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352633(CHEMBL1822311)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of JNK1 using ATF2 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM16018(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of JNK1 using ATF2 substrate by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of anisomycin-induced c-JUN phosphorylation in human HEK293T cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of TNFalpha-induced c-JUN phosphorylation in mouse B16-F10 cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed