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Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50033782
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351175(CHEMBL1818127 | US8835445, 30)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351173(CHEMBL1818129 | US8835445, 40)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351174(CHEMBL1818128 | US8835445, 31)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM18070(5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...)
Affinity DataKi:  0.0810nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351182(CHEMBL1818106)
Affinity DataKi:  0.130nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351184(CHEMBL1818117)
Affinity DataKi:  0.190nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351179(CHEMBL1818121)
Affinity DataKi:  0.240nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351176(CHEMBL1818126)
Affinity DataKi:  0.300nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351187(CHEMBL1818114)
Affinity DataKi:  0.350nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351178(CHEMBL1818122)
Affinity DataKi:  0.380nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351180(CHEMBL1818120 | US8835445, 7)
Affinity DataKi:  0.480nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351177(CHEMBL1818125)
Affinity DataKi:  0.610nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351186(CHEMBL1818115)
Affinity DataKi:  0.660nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351196(CHEMBL1818124)
Affinity DataKi:  0.760nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351185(CHEMBL1818116)
Affinity DataKi:  0.770nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351195(CHEMBL1818123)
Affinity DataKi:  0.850nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351190(CHEMBL1818110 | US8835445, 5)
Affinity DataKi:  0.890nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351189(CHEMBL1818112)
Affinity DataKi:  1.20nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.24nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351193(CHEMBL1818108)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351191(CHEMBL1818109 | US8835445, 4)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351188(CHEMBL1818113 | US8835445, 1)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351183(CHEMBL1818118)
Affinity DataKi:  3.10nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351181(CHEMBL1818119 | US8835445, 6)
Affinity DataKi:  4.40nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351174(CHEMBL1818128 | US8835445, 31)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351194(CHEMBL1818111)
Affinity DataKi:  5nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351175(CHEMBL1818127 | US8835445, 30)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351192(CHEMBL1818107)
Affinity DataKi:  9.10nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351176(CHEMBL1818126)
Affinity DataKi:  10.1nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351196(CHEMBL1818124)
Affinity DataKi:  11.1nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351178(CHEMBL1818122)
Affinity DataKi:  11.1nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351179(CHEMBL1818121)
Affinity DataKi:  12nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351187(CHEMBL1818114)
Affinity DataKi:  12.2nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351182(CHEMBL1818106)
Affinity DataKi:  20.9nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351195(CHEMBL1818123)
Affinity DataKi:  22.2nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351180(CHEMBL1818120 | US8835445, 7)
Affinity DataKi:  26.3nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351186(CHEMBL1818115)
Affinity DataKi:  27.5nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351173(CHEMBL1818129 | US8835445, 40)
Affinity DataKi:  34nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351184(CHEMBL1818117)
Affinity DataKi:  41.1nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351189(CHEMBL1818112)
Affinity DataKi:  44.1nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351183(CHEMBL1818118)
Affinity DataKi:  85nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351185(CHEMBL1818116)
Affinity DataKi:  95.6nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351193(CHEMBL1818108)
Affinity DataKi:  129nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351190(CHEMBL1818110 | US8835445, 5)
Affinity DataKi:  138nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351177(CHEMBL1818125)
Affinity DataKi:  245nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351194(CHEMBL1818111)
Affinity DataKi:  253nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351181(CHEMBL1818119 | US8835445, 6)
Affinity DataKi:  323nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351191(CHEMBL1818109 | US8835445, 4)
Affinity DataKi:  702nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM50351192(CHEMBL1818107)
Affinity DataKi:  743nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
Trius Therapeutics, San Diego, Ca 92121, United States.

Curated by ChEMBL
LigandPNGBDBM18070(5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...)
Affinity DataKi:  775nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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