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Found 13 Enz. Inhib. hit(s) with all data for entry = 50033969
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354745(CHEMBL1834084)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM32546(arylsulfonylpiperazine, 18)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM32547(arylsulfonylpiperazine, 19)
Affinity DataIC50:  13nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
Affinity DataIC50:  28.4nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354740(CHEMBL1834080)
Affinity DataIC50:  28.8nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354741(CHEMBL1834081)
Affinity DataIC50:  32.7nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354746(CHEMBL1834085)
Affinity DataIC50:  41.3nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354742(CHEMBL1834082)
Affinity DataIC50:  45nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM72094(1-(2,3-Dihydro-indol-1-yl)-2-(5,6-diphenyl-[1,2,4]...)
Affinity DataIC50:  58.1nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354743(CHEMBL1834083)
Affinity DataIC50:  66.7nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM50354744(CHEMBL1379780)
Affinity DataIC50:  102nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM72094(1-(2,3-Dihydro-indol-1-yl)-2-(5,6-diphenyl-[1,2,4]...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human 11beta HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed