Compile Data Set for Download or QSAR
maximum 50k data
Found 61 Enz. Inhib. hit(s) with all data for entry = 50034167
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358174(CHEMBL1921855)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358174(CHEMBL1921855)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358174(CHEMBL1921855)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358174(CHEMBL1921855)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358174(CHEMBL1921855)
Affinity DataEC50:  136nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358183(CHEMBL1921948)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358175(CHEMBL1921950)
Affinity DataEC50:  179nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358176(CHEMBL1921951)
Affinity DataEC50:  353nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358177(CHEMBL1921952)
Affinity DataEC50:  104nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358184(CHEMBL1921954)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358185(CHEMBL1921955)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358186(CHEMBL1921956)
Affinity DataEC50:  6.40E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55086(N-(3-chloro-4-phthalimido-phenyl)picolinamide | N-...)
Affinity DataEC50:  59.4nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55087(N-[3-chloranyl-4-[4-chloranyl-1,3-bis(oxidanyliden...)
Affinity DataEC50:  41.9nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358178(CHEMBL1921959)
Affinity DataEC50:  370nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358187(CHEMBL1921960)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataEC50:  291nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in human HEK293 at 10 uM by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human mGlu6 receptor at 10 uM by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataEC50:  2.90E+3nMAssay Description:Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358182(CHEMBL1921854)
Affinity DataEC50:  765nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358181(CHEMBL1921853)
Affinity DataEC50:  402nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358180(CHEMBL1921852)
Affinity DataEC50:  226nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55095(N-[3-chloranyl-4-[3-methyl-2,5-bis(oxidanylidene)-...)
Affinity DataEC50:  536nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phe...)
Affinity DataEC50:  491nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55093(N-[3-chloro-4-(1,3-diketo-2-azaspiro[4.5]decan-2-y...)
Affinity DataEC50:  397nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55091(N-[3-chloranyl-4-[(1S,5R)-6,6-dimethyl-2,4-bis(oxi...)
Affinity DataEC50:  686nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358173(CHEMBL1921962)
Affinity DataEC50:  246nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358179(CHEMBL1921961)
Affinity DataEC50:  376nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50358178(CHEMBL1921959)
Affinity DataEC50:  645nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55087(N-[3-chloranyl-4-[4-chloranyl-1,3-bis(oxidanyliden...)
Affinity DataEC50:  34.9nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55086(N-(3-chloro-4-phthalimido-phenyl)picolinamide | N-...)
Affinity DataEC50:  66.8nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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