Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 50046061
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50302225(escitalopram | (1S)-1-[3-(dimethylamino)propyl]-1-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093443(CHEMBL3586683)
Affinity DataKi:  24nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093442(CHEMBL3586682)
Affinity DataKi:  38nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093441(CHEMBL3586681)
Affinity DataKi:  227nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMed