Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50022613
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataKi:  160nMAssay Description:Binding affinity to LSD1 (unknown origin) using H3K4me2 as substrate assessed as apparent inhibition constant by HRP-coupled amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to LSD1 (unknown origin) using H3K4me2 as substrate assessed as apparent inhibition constant by HRP-coupled amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KCNQ1/minK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KCNQ1/minK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAryl hydrocarbon receptor(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of AhR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAryl hydrocarbon receptor(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM256459(US9487512, 3 | US10329256, Example 3 | US9944601, ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of AhR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetD-amino-acid oxidase(Human)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataKi:  5.20E+5nMAssay Description:Binding affinity to D-amino acid oxidase (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed