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Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50046359 Sort by
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of human MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetE3 ubiquitin-protein ligase Mdm2(Dog)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataKi:  11nMAssay Description:Inhibition of dog MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetE3 ubiquitin-protein ligase Mdm2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataKi:  20nMAssay Description:Inhibition of mouse MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetE3 ubiquitin-protein ligase Mdm2(Dog)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataKi:  21nMAssay Description:Inhibition of dog MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetE3 ubiquitin-protein ligase Mdm2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataKi:  66nMAssay Description:Inhibition of mouse MDM2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162023(US9051279, 73a | US9051279, 73b)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein Mdm4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human MDM4 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein Mdm4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human MDM4 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108101(CHEMBL3601399)
Affinity DataIC50:  5.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162052(US9051279, 75)
Affinity DataIC50:  9.40E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162069(US9051279, 79)
Affinity DataIC50:  1.13E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108102(CHEMBL3601400)
Affinity DataIC50:  1.32E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162069(US9051279, 79)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50:  1.70E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162157(US9051279, 140)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162142(US9051279, 125)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162147(US9051279, 130)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108100(CHEMBL3601324)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetApoptosis regulator Bcl-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Bcl2 (unknown origin) assessed as inhibition of Bcl2-Bak interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetApoptosis regulator Bcl-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Bcl2 (unknown origin) assessed as inhibition of Bcl2-Bad interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Mcl1 (unknown origin) assessed as inhibition of Mcl1-Bak interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Mcl1 (unknown origin) assessed as inhibition of Mcl1-Noxa interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetE3 ubiquitin-protein ligase XIAP(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of XIAP (unknown origin) assessed as inhibition of XIAP-BIR3 interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBaculoviral IAP repeat-containing protein 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cIAP (unknown origin) assessed as inhibition of cIAP-BIR3 interaction by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM162123(US9051279, 106)
Affinity DataKd:  2.30nMAssay Description:Inhibition of human MDM2 L33E mutant (14 to 111 residues) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)