Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50022527
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of GST tagged human LRRK2 G2019S mutant using LRRKtide as substrate in presence of KmATP by Lanthascreen TR-FRET competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LRRK2 in Tet-inducible human SH-SY5Y cells overexpressing LRRK2 assessed as inhibition of pSer935 LRRK2 by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataKi:  3.40nMAssay Description:Displacement of [35S]MLi-A from LRRK2 expressed in Tet-inducible human SHSY5Y cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 225nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 244nMAssay Description:Inhibition of MAP3K14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 428nMAssay Description:Inhibition of MAP3K5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 605nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 935nMAssay Description:Inhibition of TTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of serotonin 5-HT2B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of norepinephrine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of muscarinic M2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of peroxisome proliferator-activated receptors gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed