Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50006385
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499398(CHEMBL3735995)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataIC50: 340nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499400(CHEMBL3735106)
Affinity DataIC50: 510nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499398(CHEMBL3735995)
Affinity DataIC50: 720nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499400(CHEMBL3735106)
Affinity DataIC50: 960nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499400(CHEMBL3735106)
Affinity DataIC50: 1.06E+3nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499400(CHEMBL3735106)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499399(CHEMBL3735187)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499399(CHEMBL3735187)
Affinity DataIC50: 2.55E+3nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499398(CHEMBL3735995)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499399(CHEMBL3735187)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 4.37E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499399(CHEMBL3735187)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499398(CHEMBL3735995)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed