Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50047753
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human ATX using FS3 as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187688(CHEMBL3828650 | US10913745, Example 1.11)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ATX expressed in HEK293E cells using lysophosphatidylcholine as substrate preincubated with enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187689(CHEMBL3827513 | Example 9)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ATX expressed in HEK293E cells using lysophosphatidylcholine as substrate preincubated with enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM241106(US9409895, 17 | US9630945, 17)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ATX expressed in HEK cells using oleoyl-lysophosphatidylcholine as substrate preincubated for 20 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187690(CHEMBL3827088)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant ATX using FS3 as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187693(CHEMBL3186509)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant ATX using FS3 as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187689(CHEMBL3827513 | Example 9)
Affinity DataIC50: 7nMAssay Description:Inhibition of ATX-mediated LPA release in human plasma after 3 hrs by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187696(CHEMBL3621356)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant hemagglutinin-tagged ATX (unknown origin) using FS3 as substrate incubated for 2 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187687(CHEMBL3828733 | US11124490, Compound 918013)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human ATX using FS3 as substrate measured after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ATX in human plasma assessed as inhibition of LPA production after 2 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ATX using lysophosphatidylcholine as substrate preincubated with enzyme followed by substrate addition measured after 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 131nMAssay Description:Inhibition of recombinant human ATX using lysophosphatidylcholine as substrate by choline release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187694(CHEMBL3828165)
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant ATX using FS3 as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mouse)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant mouse ATX using lysophosphatidylcholine as substrate by choline release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187694(CHEMBL3828165)
Affinity DataKi:  270nMAssay Description:Mixed-type inhibition of human recombinant ATX using FS3 as substrate assessed as enzyme-inhibitor complex incubated for 2 hrs by Michaelis-Menten eq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187694(CHEMBL3828165)
Affinity DataKi:  280nMAssay Description:Mixed-type inhibition of human recombinant ATX using FS3 as substrate assessed as enzyme-substrate-inhibitor complex incubated for 2 hrs by Michaelis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187692(CHEMBL3827757)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant ATX in human MDA-MB-4355 cells using lysophosphatidylcholine as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187695(CHEMBL1632521)
Affinity DataKi:  390nMAssay Description:Inhibition of recombinant human C-terminal V5/His6-tagged ATX expressed in HEK293 cells assessed as choline release at 0.5 uM using oleoyl-lysophosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187691(CHEMBL3828178 | US9951026, 1-1)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant ATX in human Hep3B cells using lysophosphatidylcholine as substrate preincubated for 15 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50187695(CHEMBL1632521)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of recombinant human C-terminal V5/His6-tagged ATX expressed in HEK293 cells assessed as choline release at 0.5 uM using oleoyl-lysophosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed