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Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50047940
TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50410534(CHEMBL83116)
Affinity DataIC50:  1.59E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50410534(CHEMBL83116)
Affinity DataIC50:  1.59E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataIC50:  2.02E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataIC50:  2.04E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  2.19E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  2.20E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataIC50:  2.49E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataIC50:  2.51E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.09E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197884(CHEMBL3969733)
Affinity DataIC50:  7.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataKd:  357nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  274nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataKd:  278nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197885(CHEMBL3940890 | US20240150297, Compound AG10)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to human plasma wild type TTR assessed as dissociation constants for second binding site of TTR by isothermal titration calorimetric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197885(CHEMBL3940890 | US20240150297, Compound AG10)
Affinity DataKd:  314nMAssay Description:Binding affinity to human plasma wild type TTR assessed as dissociation constants for first binding site of TTR by isothermal titration calorimetric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransthyretin(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed