Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50009861
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 242031BDBM242031(US9415055, 2,3-Dichloro-N-[2-(4,4-difluoro-piperid...)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 242031BDBM242031(US9415055, 2,3-Dichloro-N-[2-(4,4-difluoro-piperid...)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173694BDBM173694(US9102591, 2,3-dichloro-N-[2-(6-cyclopropyl-3-pyri...)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173694BDBM173694(US9102591, 2,3-dichloro-N-[2-(6-cyclopropyl-3-pyri...)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 241720BDBM241720(US9409917, 18 | US9409917, 17)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 241720BDBM241720(US9409917, 18 | US9409917, 17)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 237018BDBM237018(US9388197, 20)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 237018BDBM237018(US9388197, 20)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533059BDBM50533059(CHEMBL4471289)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533059BDBM50533059(CHEMBL4471289)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533071BDBM50533071(CHEMBL4442874)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533071BDBM50533071(CHEMBL4442874)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533060BDBM50533060(CHEMBL4464059)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533060BDBM50533060(CHEMBL4464059)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533062BDBM50533062(CHEMBL4573316)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533062BDBM50533062(CHEMBL4573316)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533070BDBM50533070(CHEMBL4515801)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533070BDBM50533070(CHEMBL4515801)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533065BDBM50533065(CHEMBL4465051)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533065BDBM50533065(CHEMBL4465051)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533067BDBM50533067(CHEMBL4546974)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533067BDBM50533067(CHEMBL4546974)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533068BDBM50533068(CHEMBL4450832)
Affinity DataIC50: 8.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533068BDBM50533068(CHEMBL4450832)
Affinity DataIC50: 8.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173295BDBM173295(US9096596, 33 | US9604982, Example 33 | US10323032...)
Affinity DataIC50: 8.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173295BDBM173295(US9096596, 33 | US9604982, Example 33 | US10323032...)
Affinity DataIC50: 8.5nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533069BDBM50533069(CHEMBL4077415)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533069BDBM50533069(CHEMBL4077415)
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533064BDBM50533064(CHEMBL4538740)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533061BDBM50533061(CHEMBL4469592)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533064BDBM50533064(CHEMBL4538740)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173337BDBM173337(US9096596, 58 | US9604982, Example 58 | US10323032...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173337BDBM173337(US9096596, 58 | US9604982, Example 58 | US10323032...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533064BDBM50533064(CHEMBL4538740)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533064BDBM50533064(CHEMBL4538740)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533061BDBM50533061(CHEMBL4469592)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533061BDBM50533061(CHEMBL4469592)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced pore formation incubated for 20 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533061BDBM50533061(CHEMBL4469592)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173337BDBM173337(US9096596, 58 | US9604982, Example 58 | US10323032...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173337BDBM173337(US9096596, 58 | US9604982, Example 58 | US10323032...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533066BDBM50533066(CHEMBL4567755)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533066BDBM50533066(CHEMBL4567755)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533067BDBM50533067(CHEMBL4546974)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173375BDBM173375(US9096596, 88 | US9604982, Example 88 | US10323032...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173375BDBM173375(US9096596, 88 | US9604982, Example 88 | US10323032...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533067BDBM50533067(CHEMBL4546974)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 267176BDBM267176(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-oxazol-5-...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 267176BDBM267176(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-oxazol-5-...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173375BDBM173375(US9096596, 88 | US9604982, Example 88 | US10323032...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 173375BDBM173375(US9096596, 88 | US9604982, Example 88 | US10323032...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
Displayed 1 to 50 (of 76 total ) | Next | Last >>
Jump to: