Compile Data Set for Download or QSAR
maximum 50k data
Found 32 Enz. Inhib. hit(s) with all data for entry = 50001920
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  16nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  16nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Affinity DataKi:  38nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Affinity DataKi:  38nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Affinity DataKi:  60nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018737(1,2,3,4,6,7,12,12b-Octahydro-indolo[2,3-a]quinoliz...)
Affinity DataKi:  60nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  110nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018736(1,3,4,5,6,11b-Hexahydro-2H-11-oxa-4a-aza-benzo[a]f...)
Affinity DataKi:  110nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018741(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Affinity DataKi:  195nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018741(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Affinity DataKi:  195nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018740(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Affinity DataKi:  347nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018740(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Affinity DataKi:  350nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018738(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Affinity DataKi:  537nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018738(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Affinity DataKi:  540nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018738(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Affinity DataKi:  660nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018738(1,2,3,4,5,6,11,11b-Octahydro-4a,10,11-triaza-benzo...)
Affinity DataKi:  661nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018741(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Affinity DataKi:  1.10E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018741(4,7,8,9,10,10a-Hexahydro-5H-thieno[2,3-a]quinolizi...)
Affinity DataKi:  1.10E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018735(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Affinity DataKi:  2.00E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018735(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Affinity DataKi:  2.00E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018740(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Affinity DataKi:  2.80E+3nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018740(4,7,8,9,10,10a-Hexahydro-5H-thiazolo[4,5-a]quinoli...)
Affinity DataKi:  2.82E+3nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018735(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Affinity DataKi:  3.24E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018735(5,6,7,8,9,10-Hexahydro-4bH-4,8a-diaza-phenanthrene...)
Affinity DataKi:  3.25E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018734(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Affinity DataKi:  9.55E+3nMAssay Description:Compound was evaluated for log 1/Ki at alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018734(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Affinity DataKi:  9.60E+3nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018734(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Affinity DataKi:  2.40E+4nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50018734(1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinol...)
Affinity DataKi:  2.40E+4nMAssay Description:Affinity to alpha-1 adrenergic receptor by the displacement of [3H]-prazosin from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed