Found 17 Enz. Inhib. hit(s) with all data for entry = 50001440 TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as reduction in amyloid beta 42 levelMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 110nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition over 48 hr of BAL strain HIV infrction of HeLa Magi cells expressing CCR5More data for this Ligand-Target Pair
