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Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50000456
TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.574nMAssay Description:Displacement of [33P]-S1P from human S1P5 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.626nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.772nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 4(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  29nMAssay Description:Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.45E+3nMAssay Description:Displacement of [33P]-S1P from rat S1P1 receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.63E+3nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250632(CHEMBL4100785)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250636(CHEMBL4085321)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250623(CHEMBL4103252)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250629(CHEMBL4074505)
Affinity DataEC50:  6.80E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50:  0.920nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250615(CHEMBL4077888)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250636(CHEMBL4085321)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Rat)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.0286nMAssay Description:Agonist activity at rat S1P1 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250632(CHEMBL4100785)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250614(CHEMBL4095920)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250628(CHEMBL4062652)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250611(CHEMBL4074023)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361036(CHEMBL1935575)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250612(CHEMBL4059628)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250614(CHEMBL4095920)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250615(CHEMBL4077888)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250616(CHEMBL4101237)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250617(CHEMBL4065871)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250618(CHEMBL4092538)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250619(CHEMBL4071753)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250620(CHEMBL4084786)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250621(CHEMBL4075067)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250622(CHEMBL4095501)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250623(CHEMBL4103252)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250626(CHEMBL4093077)
Affinity DataEC50:  5.50E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250627(CHEMBL4065407)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250611(CHEMBL4074023)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250628(CHEMBL4062652)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 3(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50361036(CHEMBL1935575)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250612(CHEMBL4059628)
Affinity DataEC50:  540nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250629(CHEMBL4074505)
Affinity DataEC50:  0.580nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250616(CHEMBL4101237)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250617(CHEMBL4065871)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250618(CHEMBL4092538)
Affinity DataEC50:  0.580nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250619(CHEMBL4071753)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250630(CHEMBL4063139)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250621(CHEMBL4075067)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 5(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.330nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50:  0.190nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine 1-phosphate receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250614(CHEMBL4095920)
Affinity DataEC50:  1.20nMAssay Description:Displacement of [33P]-S1P from human S1P1 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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