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Found 19 Enz. Inhib. hit(s) with all data for entry = 50001801
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50:  200nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50366305(CHEBI:70328 | CHEMBL445599)
Affinity DataIC50:  300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50109833(Arzanol)
Affinity DataIC50:  400nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369678(CHEMBL3770253)
Affinity DataIC50:  400nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369679(CHEMBL2006643)
Affinity DataIC50:  430nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50193079(CHEBI:5834 | CHEMBL1237210)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mPGES1 (unknown origin) assessed as reduction in conversion of PGH to PGE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50056919(3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 3...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369681(CHEMBL4163039)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369680(CHEMBL4170957)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241262((3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-a...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241260((3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-h...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50213683(CHEMBL218693 | carnosol)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 5 mins by HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241261((3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-h...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed