Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50002588
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460206BDBM50460206(CHEMBL4228510)
Affinity DataIC50: 540nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50155929BDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 680nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460206BDBM50460206(CHEMBL4228510)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50042944BDBM50042944(cid_638278 | (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hyd...)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460206BDBM50460206(CHEMBL4228510)
Affinity DataKi:  2.89E+3nMAssay Description:Competitive inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate addition b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50140241BDBM50140241(CHEBI:40279 | Allopurinol | Aloral | Aluline 100 |...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460206BDBM50460206(CHEMBL4228510)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460196BDBM50460196(CHEMBL4228911)
Affinity DataIC50: 5.42E+3nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460196BDBM50460196(CHEMBL4228911)
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460199BDBM50460199(CHEMBL4225876)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460214BDBM50460214(CHEMBL4224753)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460195BDBM50460195(CHEMBL4226321)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460203BDBM50460203(CHEMBL4229108)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460198BDBM50460198(CHEMBL4227459)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460198BDBM50460198(CHEMBL4227459)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460196BDBM50460196(CHEMBL4228911)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460198BDBM50460198(CHEMBL4227459)
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460204BDBM50460204(CHEMBL4226535)
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460212BDBM50460212(CHEMBL4227524)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460211BDBM50460211(CHEMBL4226015)
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460203BDBM50460203(CHEMBL4229108)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460212BDBM50460212(CHEMBL4227524)
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460202BDBM50460202(CHEMBL4224958)
Affinity DataIC50: 3.88E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460197BDBM50460197(CHEMBL4225870)
Affinity DataIC50: 3.91E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460203BDBM50460203(CHEMBL4229108)
Affinity DataIC50: 3.95E+4nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460213BDBM50460213(CHEMBL4227733)
Affinity DataIC50: 4.43E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460199BDBM50460199(CHEMBL4225876)
Affinity DataIC50: 4.57E+4nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460201BDBM50460201(CHEMBL4228390)
Affinity DataIC50: 4.89E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460200BDBM50460200(CHEMBL4225751)
Affinity DataIC50: 5.05E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460216BDBM50460216(CHEMBL4225688)
Affinity DataIC50: 5.25E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460205BDBM50460205(CHEMBL4227343)
Affinity DataIC50: 5.81E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460208BDBM50460208(CHEMBL4229154)
Affinity DataIC50: 6.43E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460207BDBM50460207(CHEMBL4224890)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460210BDBM50460210(CHEMBL4226441)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460209BDBM50460209(CHEMBL4225990)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Soochow University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460215BDBM50460215(CHEMBL4228302)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed