Compile Data Set for Download or QSAR
maximum 50k data
Found 41 Enz. Inhib. hit(s) with all data for entry = 50002966
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1(Thr37/46) peptide as substrate measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PI3K p120gamma using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465281(CHEMBL4284400)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1(Thr37/46) peptide as substrate measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465281(CHEMBL4284400)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  16nMAssay Description:Inhibition of human PI3K p110delta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465281(CHEMBL4284400)
Affinity DataIC50:  19nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1(Thr37/46) peptide as substrate measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465292(CHEMBL4279898)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465289(CHEMBL4276933)
Affinity DataIC50:  28nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465282(CHEMBL4280265)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465288(CHEMBL4294409)
Affinity DataIC50:  34nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  34nMAssay Description:Inhibition of human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465277(CHEMBL4294612)
Affinity DataIC50:  45nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465290(CHEMBL4280614)
Affinity DataIC50:  49nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465286(CHEMBL4291635)
Affinity DataIC50:  49nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465291(CHEMBL4277571)
Affinity DataIC50:  54nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465285(CHEMBL4280989)
Affinity DataIC50:  57nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465279(CHEMBL4288222)
Affinity DataIC50:  64nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465281(CHEMBL4284400)
Affinity DataIC50:  66nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465279(CHEMBL4288222)
Affinity DataIC50:  67nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465287(CHEMBL4295052)
Affinity DataIC50:  77nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465287(CHEMBL4295052)
Affinity DataIC50:  78nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465284(CHEMBL4288517)
Affinity DataIC50:  81nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465278(CHEMBL4288258)
Affinity DataIC50:  89nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465283(CHEMBL4281223)
Affinity DataIC50:  99nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465284(CHEMBL4288517)
Affinity DataIC50:  106nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465277(CHEMBL4294612)
Affinity DataIC50:  109nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465289(CHEMBL4276933)
Affinity DataIC50:  119nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465291(CHEMBL4277571)
Affinity DataIC50:  138nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465280(CHEMBL4287809)
Affinity DataIC50:  141nMAssay Description:Inhibition of PI3Kalpha in human MCF7 cells assessed as reduction in AKT phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465292(CHEMBL4279898)
Affinity DataIC50:  153nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465286(CHEMBL4291635)
Affinity DataIC50:  163nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465283(CHEMBL4281223)
Affinity DataIC50:  198nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465290(CHEMBL4280614)
Affinity DataIC50:  223nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465285(CHEMBL4280989)
Affinity DataIC50:  246nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465282(CHEMBL4280265)
Affinity DataIC50: >400nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465288(CHEMBL4294409)
Affinity DataIC50: >400nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL
LigandPNGBDBM50465280(CHEMBL4287809)
Affinity DataIC50: >400nMAssay Description:Inhibition of mTOR in human MCF7 cells assessed as reduction in P70S6K phosphorylation after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed