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Found 4 Enz. Inhib. hit(s) with all data for entry = 50002738
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50462275(CHEMBL4249954)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant GST-tagged human PDE9A2 expressed in insect cells using cGMP as substrate after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50210628(CHEMBL3946861)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human PDE3A (484 to 1141 residues) expressed in Sf9 cells using cAMP as substrate after 60 mins by IM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM14754(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant rat PDE10A expressed in Sf9 insect cells using cGMP or cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50462276(CHEMBL4244897)
Affinity DataIC50:  73nMAssay Description:Inhibition of recombinant human PDE11A4 expressed in Sf9 insect cells using [3H]cGMP or [3H]cAMP as substrate after 10 mins by scintillation counting...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed