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Report error Found 252 Enz. Inhib. hit(s) with all data for entry = 50001193
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.0120nMAssay Description:Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEndothelin-1 receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.0230nMAssay Description:Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetC-C chemokine receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.0810nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCholecystokinin receptor type A(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.120nMAssay Description:Displacement of [125I]CCK-8s from human recombinant CCK1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNeuropeptide Y receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMelatonin receptor type 1A(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.170nMAssay Description:Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.170nMAssay Description:Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGalanin receptor type 2(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.190nMAssay Description:Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMelanocortin receptor 4(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.210nMAssay Description:Displacement of [125I]NDP-alpha -MSH from human recombinant MC4 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.210nMAssay Description:Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetC-X-C chemokine receptor type 2(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNeurotensin receptor type 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.25nMAssay Description:Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.25nMAssay Description:Displacement of [3H]-prazosin from rat alpha1 adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNeuropeptide Y receptor type 2(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.280nMAssay Description:Displacement of [125I]peptide YY from human Y2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSomatostatin receptor type 1/2/3/4/5(Mouse)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]Tyr11-somatostatin-14 from mouse SST receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392066(US10301272, Example 6/64)
Affinity DataIC50:  0.370nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 7(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.390nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetType-1 angiotensin II receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.470nMAssay Description:Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetVasoactive intestinal polypeptide receptor 1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.470nMAssay Description:Displacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAdenosine receptor A1(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [3H]-DPCPX from human recombinant adenosine A1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.640nMAssay Description:Displacement of [3H]ketanserin human recombinant 5-HT2A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392013(US10301272, Example 6/11)
Affinity DataIC50:  0.690nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392136(US10301272, Example 14/6)
Affinity DataIC50:  0.710nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M3(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.730nMAssay Description:Displacement of [3H]4-DAMP from human recombinant M3 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.940nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.980nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271670(CHEMBL4126317)
Affinity DataIC50:  1nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50044179(CHEMBL3314002 | US10301272, Example 7/4)
Affinity DataIC50:  1.10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVasopressin V1a receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]U69593 from human kappa receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392102(US10301272, Example 8/7)
Affinity DataIC50:  1.20nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSubstance-K receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271669(CHEMBL4127932)
Affinity DataIC50:  1.30nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392138(US10301272, Example 15 | US10301272, Example 16)
Affinity DataIC50:  1.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392075(US10301272, Example 7/8)
Affinity DataIC50:  1.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392168(US10301272, Example 20 | trans-3-(4-(Cyclohexylmet...)
Affinity DataIC50:  1.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392012(US10301272, Example 6/10)
Affinity DataIC50:  1.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392074(US10301272, Example 7/7)
Affinity DataIC50:  1.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]-imipramine from recombinant human 5-HT transporter after 60 mins by scintillation counting relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271671(CHEMBL4127282)
Affinity DataIC50:  1.80nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271677(CHEMBL4130294)
Affinity DataIC50:  1.80nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]7-OH-DPAT from human recombinant dopamine D2S receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392144(US10301272, Example 15/6)
Affinity DataIC50:  1.90nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271664(CHEMBL4128687)
Affinity DataIC50:  2.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392021(US10301272, Example 6/19)
Affinity DataIC50:  2.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392006(US10301272, Example 6/4)
Affinity DataIC50:  2.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM392080(US10301272, Example 7/13)
Affinity DataIC50:  3.20nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

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