BindingDB PrimarySearch_ki

Found 142 Enz. Inhib. hit(s) with all data for entry = 50006775

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM279948(US10028961, Compound 101 | US10172864, Compound 10...)

IC50: 0.0400nMAssay Description:Inhibition of IDH1 R132G mutant (unknown origin) assessed as reduction in 2-HG levels after 90 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM279948(US10028961, Compound 101 | US10172864, Compound 10...)

IC50: 0.0400nMAssay Description:Inhibition of IDH1 R132S mutant (unknown origin) assessed as reduction in 2-HG levels after 90 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM279948(US10028961, Compound 101 | US10172864, Compound 10...)

IC50: 0.0400nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in 2-HG levels after 90 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM279948(US10028961, Compound 101 | US10172864, Compound 10...)

IC50: 0.0400nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in 2-HG levels after 90 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503258(CHEMBL4439421)

IC50: 2nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503257(CHEMBL4463644)

IC50: 2nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM412559(US10399972, Example 50)

IC50: 3.5nMAssay Description:Inhibition of IDH1 RI32C mutant (unknown origin) by kinase-Glo luminescent assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503257(CHEMBL4463644)

IC50: 6nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) using alpha-KG as substrate after 90 mins in presence of NADPH by RF/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503258(CHEMBL4439421)

IC50: 6nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) using alpha-KG as substrate after 90 mins in presence of NADPH by RF/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM279948(US10028961, Compound 101 | US10172864, Compound 10...)

IC50: 7nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in 2-HG levels after 90 mins in presence of NADPH by resazurin-based assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503281(CHEMBL4586919 | US10696665, Example 25)

IC50: 8.90nMAssay Description:Inhibition of N-terminal His-tagged IDH1 RI32C mutant (unknown origin) expressed in Escherichia coli using alpha-KG and NADPH substrate assessed as s...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)

IC50: 9nMAssay Description:Inhibition of IDH1 RI32C mutant in human HT1080 cells assessed as reduction in intracellular 2-HG levels after 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM377574(4-{[(1S)-1-(6-chloro-2-oxo- | US10266495, Compound...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383739(US10280150, Cmpd No I-22 | US10550099, Compound I-...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM412533(US10399972, Example 24 | {3,9-difluoro-8-[(1S,4S)-...)

IC50: <10nMAssay Description:Inhibition of IDH1 RI32C mutant (unknown origin) by kinase-Glo luminescent assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM445370((S)-1-(2-(((S)-1-(1-(4-(trifluoromethyl)phenyl)-1H...)

IC50: 10nMAssay Description:Inhibition of IDH1 in human HT1080 cells assessed as decrease in 2-HG levels after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM377574(4-{[(1S)-1-(6-chloro-2-oxo- | US10266495, Compound...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503280(CHEMBL4469055 | US11311527, Cpd ID I-26 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503262(CHEMBL4473981)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383754(US10280150, Cmpd No I-37 | US10550099, Compound I-...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM415798(US10442772, Example 2-169-1)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate by by luminescence based assa...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383860(US10280150, Cmpd No I-143 | US10550099, Compound I...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503280(CHEMBL4469055 | US11311527, Cpd ID I-26 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383739(US10280150, Cmpd No I-22 | US10550099, Compound I-...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM415782(US10442772, Example 2-164 | US10442772, Example 2-...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate by by luminescence based assa...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM412531((3,9-difluoro-8- ((3R,3aR,6R,6aR)-hexahydro- 3,6-e...)

IC50: <10nMAssay Description:Inhibition of IDH1 RI32C mutant (unknown origin) by kinase-Glo luminescent assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM412530((3,9-difluoro-8-(6-oxa-2- azaspiro[3.5]nonan-2-yl)...)

IC50: <10nMAssay Description:Inhibition of IDH1 RI32C mutant (unknown origin) by kinase-Glo luminescent assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503263(CHEMBL4464313 | US11311527, Cpd ID I-23 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383754(US10280150, Cmpd No I-37 | US10550099, Compound I-...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM404661(US10344004, Test compound Table 3 | US10442772, Ex...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate by by luminescence based assa...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM390498((�) 3-(6-methyl-2-{[4-(trifluoromethoxy)phe...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate by by luminescence based assa...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503260(CHEMBL4456610 | US11311527, Cpd ID I-27 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503261(CHEMBL4459496)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503262(CHEMBL4473981)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM383860(US10280150, Cmpd No I-143 | US10550099, Compound I...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503263(CHEMBL4464313 | US11311527, Cpd ID I-23 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503260(CHEMBL4456610 | US11311527, Cpd ID I-27 | US113762...)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503261(CHEMBL4459496)

IC50: <10nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 45 mins by by d...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503281(CHEMBL4586919 | US10696665, Example 25)

IC50: 11nMAssay Description:Inhibition of N-terminal His-tagged IDH1 RI32H mutant (unknown origin) expressed in Escherichia coli using alpha-KG and NADPH substrate assessed as s...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)

IC50: 15nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alphaKG as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)

IC50: 17nMAssay Description:Inhibition of IDH1 R132G mutant (unknown origin) using alphaKG as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503275(CHEMBL4447740 | US11203586, Example 10)

IC50: <20nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) by NADPH depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503243(CHEMBL4560565 | US11111240, Example 12)

IC50: <20nMAssay Description:Inhibition of IDH1 RI32H mutant in human HT1080 cells assessed as reduction in intracellular 2-HG levels after 24 hrs by resazurin fluorescence based...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503243(CHEMBL4560565 | US11111240, Example 12)

IC50: <20nMAssay Description:Inhibition of IDH1 RI32C mutant in human U87 cells assessed as reduction in intracellular 2-HG levels after 24 hrs by resazurin fluorescence based as...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503245(CHEMBL4462489)

IC50: 27nMAssay Description:Inhibition of N-terminal His-tagged IDH1 R132C mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503283(CHEMBL4469739)

IC50: 28nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503279(CHEMBL4449563)

IC50: 28nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 minsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503245(CHEMBL4462489)

IC50: 29nMAssay Description:Inhibition of N-terminal His-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Isocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503278(CHEMBL4456102 | US10745383, Example 3)

IC50: 32nMAssay Description:Inhibition of IDH2 R172K mutant (40 to end residues) (unknown origin) using alpha-KG as substrate after 120 mins in presence of NADPH by resazurin-ba...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Isocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50503255(CHEMBL4536525)

IC50: 41nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) by NADPH depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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