Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50022533
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human ZR-75-1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human U-2940 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human REC1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human BJAB cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human MINO cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human MAVER-1 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2nMAssay Description:Inhibition of PRMT5 in human MDA-MB-468 cells assessed as decrease in SDMA level incubated for 3 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataEC50:  2.10nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on SDMA level incubated for 3 days by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on SDMA level incubated for 3 days by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  3nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  3nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as substrate assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using Sm3d as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H2A as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using H4 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataKi:  9.80nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate assesse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 19nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using HNRNPH1 as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  22nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on SESN1 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataKi:  43nMAssay Description:Uncompetitive inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using [3H]SAM as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataKi:  46nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 46nMAssay Description:Inhibition of Flag-tagged human PRMT5/his-tagged MEP50 (unknown origin) expressed in baculovirus expression system using FUBP1 as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  50nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on BAX expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  55nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on CDKN1 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  167nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on MDM2 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  177nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on PHLDA3 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  212nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on TRIM22 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  214nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on EGR2 expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataEC50:  323nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as effect on GADD45A expression incubated for 2 to 4 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed