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Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50002851
TargetCytochrome P450 2C9(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  530nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  560nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  3.81E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  4.23E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50:  1.84E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50030765(NPI-2358 | Plinabulin)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed