Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50019139
TargetTransforming growth factor beta-2 proprotein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615664BDBM50615664(CHEMBL5288544)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 493757BDBM493757(US10988455, Example 1(xcv))
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human adenosine A2A receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTransforming growth factor beta-2 proprotein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 172452BDBM172452(US9090625, 4 | US9260450, 4 | US9938289, 4 | US202...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50542976BDBM50542976(CHEMBL4636606 | US11535615, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615665BDBM50615665(CHEMBL5267324)
Affinity DataIC50: 11nMAssay Description:Inhibition of ALK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239947BDBM50239947(US9872852, Example 202 | CHEMBL4089730 | US2023030...)
Affinity DataIC50: 18nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetEctonucleoside triphosphate diphosphohydrolase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615669BDBM50615669(CHEMBL5277365)
Affinity DataIC50: 50nMAssay Description:Inhibition of human NTPDase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTransforming growth factor beta-2 proprotein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50015640BDBM50015640(LY-2157299 | GALUNISERTIB)
Affinity DataIC50: 56nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534854BDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Agonist activity at human RORgammatMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetArginase-1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511658BDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human recombinant ARG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559854BDBM50559854(Motolimod | VTX-2337 | VTX-378)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597797BDBM50597797(CHEMBL4459180)
Affinity DataIC50: 110nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50239943BDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 223080BDBM223080((E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dih...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human N-terminal Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50511658BDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50: 296nMAssay Description:Inhibition of recombinant human ARG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-2, mitochondrial(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50561034BDBM50561034(CHEMBL4244287)
Affinity DataKi:  310nMAssay Description:Competitive inhibition of human ARG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetEctonucleoside triphosphate diphosphohydrolase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615668BDBM50615668(CHEMBL5283491)
Affinity DataIC50: 500nMAssay Description:Inhibition of human NTPDase1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615667BDBM50615667(CHEMBL5289982)
Affinity DataIC50: 740nMAssay Description:Inhibition of human ARG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615666BDBM50615666(CHEMBL5265778)
Affinity DataEC50:  800nMAssay Description:Inverse agonist activity at human RORgammatMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTransforming growth factor beta-2 proprotein(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615663BDBM50615663(CHEMBL5279930)
Affinity DataIC50: 970nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetArginase-1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50008099BDBM50008099(CHEMBL1234777)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ARG1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22985BDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataEC50:  6.50E+3nMAssay Description:Antagonist activity at CXCR4 receptor in human MIA PaCa-2 cells assessed as reduction in forskolin-stimulated inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed