Compile Data Set for Download or QSAR
Report error Found 232 Enz. Inhib. hit(s) with all data for entry = 50006788 Sort by
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503350(CHEMBL310840)
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50235342(NU-6102 | CHEMBL319467)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CDK2/cyclin A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM7534(1H-pyrazolo[3,4-b]quinoxalin-3-amine | pyrazolo[3,...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 13nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503354(CHEMBL4474459)
Affinity DataIC50: 13nMAssay Description:Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 13nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503350(CHEMBL310840)
Affinity DataIC50: 14nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 14nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50235342(NU-6102 | CHEMBL319467)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503354(CHEMBL4474459)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50: 22nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50235342(NU-6102 | CHEMBL319467)
Affinity DataIC50: 22nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50004205(MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...)
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM65549(cid_644215 | 3-[[4-[2-(3-chloroanilino)pyrimidin-4...)
Affinity DataIC50: 26nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50: 26nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50073765(N*2*-((1R,2S)-2-Amino-cyclohexyl)-N*6*-(3-chloro-p...)
Affinity DataIC50: 26nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50073765(N*2*-((1R,2S)-2-Amino-cyclohexyl)-N*6*-(3-chloro-p...)
Affinity DataIC50: 26nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50: 27nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM148264(US8962630, 74 | Ribociclib | LEE011 | Kisqali | 7-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50202299(CHEMBL411491)
Affinity DataIC50: 31nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50073765(N*2*-((1R,2S)-2-Amino-cyclohexyl)-N*6*-(3-chloro-p...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50347924(CHEMBL1802728)
Affinity DataIC50: 35nMAssay Description:Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 38nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50202299(CHEMBL411491)
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50073765(N*2*-((1R,2S)-2-Amino-cyclohexyl)-N*6*-(3-chloro-p...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50205472(CHEMBL393929 | CHEMBL261644 | (Z)-5-(quinolin-6-yl...)
Affinity DataIC50: 47nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50: 49nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973(4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)t...)
Affinity DataIC50: 51nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50: 55nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 59nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 66nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50347924(CHEMBL1802728)
Affinity DataIC50: 67nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50: 69nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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