Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 232 Enz. Inhib. hit(s) with all data for entry = 50006788
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM65549(3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50:  3nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50503350(CHEMBL310840)
Affinity DataIC50:  6nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  6nMAssay Description:Inhibition of human CDK2/cyclin A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50:  7nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM7534(1H-pyrazolo[3,4-b]quinoxalin-3-amine | pyrazolo[3,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase B(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503354(CHEMBL4474459)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM65549(3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50503350(CHEMBL310840)
Affinity DataIC50:  14nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  14nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  14nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503354(CHEMBL4474459)
Affinity DataIC50:  18nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  18nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50:  22nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  22nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  23nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM65549(3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridi...)
Affinity DataIC50:  26nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  26nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50:  26nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50503353(Su-9516)
Affinity DataIC50:  27nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM148264(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Affinity DataIC50:  30nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50202299(CHEMBL411491)
Affinity DataIC50:  31nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAurora kinase B(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50347924(CHEMBL1802728)
Affinity DataIC50:  35nMAssay Description:Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50:  38nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  41nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50202299(CHEMBL411491)
Affinity DataIC50:  41nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  46nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  46nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50205472((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Affinity DataIC50:  47nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM153742(Oxindole (Scaffold V))
Affinity DataIC50:  49nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataIC50:  51nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  55nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  59nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  66nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50347924(CHEMBL1802728)
Affinity DataIC50:  67nMAssay Description:Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50012188(6BIO)
Affinity DataIC50:  69nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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