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Report error Found 177 Enz. Inhib. hit(s) with all data for entry = 50006798 Sort by
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to recombinant human full length DNA-tagged BRD4 short isoform expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to recombinant human DNA-tagged BRD9 (130 to 259 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant human full length DNA-tagged TAF11D bromodomain 2 (1523 to 1654 residues) expressed in bacterial expression system by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  5nMAssay Description:Binding affinity to recombinant human full length DNA-tagged TAF1L bromodomain 2 (1523 to 1654 residues) expressed in bacterial expression system by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to recombinant human DNA-tagged CECR2 (423 to 543 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50503407(CHEMBL4440829)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321463(6-(but-3-en-1-yl)-4-(3-(difluoromethoxy)-5-(morpho...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321467(6-but-3-enyl-4-[3-ethyl-7-(morpholine-4-carbonyl)b...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503399(CHEMBL4441257)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503413(CHEMBL4566599)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503404(CHEMBL4455513)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503408(CHEMBL4459660)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321460(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321465(US10183009, Example 57 | 6-but-3-enyl-4-[3-methyl-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503398(CHEMBL4445482)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503412(CHEMBL4459431)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321461(6-but-3-enyl-4-[3-fluoro-5-(morpholine-4-carbonyl)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503403(CHEMBL4463398)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503411(CHEMBL4448345)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503409(CHEMBL4465624)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503400(CHEMBL4483624)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataIC50: 38nMAssay Description:Inhibition of fluorescent-tagged ligand from nanoLuc fused N-terminal TAF1 bromodomain 2 (unknown origin) expressed in 293T cells by luciferase repor...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503402(CHEMBL4466746)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503405(CHEMBL4518929)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503401(CHEMBL4470836)
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50503410(CHEMBL4572531)
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503404(CHEMBL4455513)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 300nMAssay Description:Inhibition of fluorescent-tagged ligand from nanoLuc fused full length BRD4 (unknown origin) expressed in 293T cells by luciferase reporter gene base...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321460(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321465(US10183009, Example 57 | 6-but-3-enyl-4-[3-methyl-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503411(CHEMBL4448345)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503410(CHEMBL4572531)
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503407(CHEMBL4440829)
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321467(6-but-3-enyl-4-[3-ethyl-7-(morpholine-4-carbonyl)b...)
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321463(6-(but-3-en-1-yl)-4-(3-(difluoromethoxy)-5-(morpho...)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321467(6-but-3-enyl-4-[3-ethyl-7-(morpholine-4-carbonyl)b...)
Affinity DataIC50: 620nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503402(CHEMBL4466746)
Affinity DataIC50: 690nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321463(6-(but-3-en-1-yl)-4-(3-(difluoromethoxy)-5-(morpho...)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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