Compile Data Set for Download or QSAR
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Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50003204
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of full length SIRT6 (unknown origin) using acetylated H3K9 peptide as substrate after 2 hrs in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  4.50E+5nMAssay Description:Inhibition of human SIRT6 preincubated for 5 mins in presence of substrate followed enzyme addition measured after 5 to 10 mins in presence of NAD by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant His-tagged full-length Sirt1 expressed in Escherichia coli BL21 DE3 Rosetta2 using acetyl-p53-peptide as substrate by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  4.45E+5nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of NAM by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  2.27E+5nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins by fluorescence-based SDS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  2.90E+4nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  3.30E+4nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)