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Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50011531
TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataKi:  600nMAssay Description:Competitive inhibition of human CSE using varying levels of L-Cys as substrate and fixed PLP levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548267(CHEMBL4761159)
Affinity DataKi:  4.90E+3nMAssay Description:Competitive inhibition of human CSE using varying levels of L-Cys as substrate and fixed PLP levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human CSE using L-Cys as the substrate in presence of 0.01% Triton X-100 by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human CSE using L-Cys as the substrate in presence of 0.025% Triton X-100 by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human CSE by methylene blue methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine beta-synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CBS (unknown origin) by AzMC based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548267(CHEMBL4761159)
Affinity DataIC50:  6.20E+3nMAssay Description:Non-covalent reversible inhibition of human CSEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548267(CHEMBL4761159)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548267(CHEMBL4761159)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM64987(5-nitro-8-quinolinol | 5-nitroquinolin-8-ol | 8-HY...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548267(CHEMBL4761159)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine beta-synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CBS (unknown origin) by methylene blue methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  3.47E+4nMAssay Description:Inhibition of wild type human CSE expressed in HEK293T cells assessed as reduction in H2S contentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  4.32E+4nMAssay Description:Inhibition of CSE in mouse RAW264.7 cells assessed as reduction in endogenous H2S level by AzMC probe based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548276(CHEMBL4790519)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548277(CHEMBL4787936)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548274(CHEMBL1978705)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548275(CHEMBL2001273)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548273(CHEMBL4740853)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM25469(2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-o...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548268(CHEMBL4759091)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548269(CHEMBL1981644)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM80987(2-chloranyl-3-(4-methylpiperazin-1-yl)naphthalene-...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548270(CHEMBL4749230)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50447761(CHEMBL60908)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548271(CHEMBL1098773)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM80755(6-amino-7-bromo-quinoline-5,8-quinone | 6-amino-7-...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548272(CHEMBL4741600)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM114207(Kalafungin | MLS002920403 | SMR001797995 | cid_283...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50235883(CHEMBL1702248)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine beta-synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  5.42E+4nMAssay Description:Inhibition of human CBS by methylene blue methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548279(CHEMBL4784652)
Affinity DataIC50:  5.99E+4nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548280(CHEMBL1205573)
Affinity DataIC50:  1.43E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548281(CHEMBL4781645)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM26193(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60918(5-Amino-2-hydroxy-benzoic acid | MESALAMINE | MLS0...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548283(C. i. mordant yellow 5 | Dipentum | Olsalazine | U...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548282(CHEMBL4743182)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50548278(CHEMBL4748507)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  2.45E+5nMAssay Description:Inhibition of human CSE R119K mutant expressed in HEK293T cells assessed as reduction in H2S contentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  2.83E+5nMAssay Description:Inhibition of human CSE Y114F mutant expressed in HEK293T cells assessed as reduction in H2S contentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  3.71E+5nMAssay Description:Inhibition of human CSE R119A mutant expressed in HEK293T cells assessed as reduction in H2S contentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM367671(US10227314, Compound 2-aminopent-4-ynoic acid)
Affinity DataIC50:  3.71E+5nMAssay Description:Inhibition of CSE in mouse RAW264.7 cells assessed as reduction in endogenous H2S level by AzMC probe based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine beta-synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50: >6.50E+5nMAssay Description:Inhibition of wild type human CBS expressed in HEK293T cells assessed as reduction in H2S contentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCystathionine gamma-lyase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to human CSE by ITC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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