Compile Data Set for Download or QSAR
Report error Found 119 Enz. Inhib. hit(s) with all data for entry = 50022588
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataKd:  18nMAssay Description:Binding affinity to N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataKd:  36nMAssay Description:Binding affinity to N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657583(US20240083857, Example 262 | N-[1-(5-{2-[(dimethyl...)
Affinity DataIC50: 40nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657571(6,7-dimethoxy-2-methyl-N-[1-(5-{2-[(methylamino)me...)
Affinity DataIC50: 41nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657618(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 46nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657619(2-{[2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-y...)
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652970(CHEMBL5687017)
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657688(N-[1-(5-{2-[(ethylamino)methyl]phenyl}thiophen-2-y...)
Affinity DataIC50: 55nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 61nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657638(N-[1-{5-[2-(azetidin-1-ylmethyl)phenyl]thiophen-2-...)
Affinity DataIC50: 76nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657573(N-[1-{5-[2-(aminomethyl)phenyl]thiophen-2-yl}ethyl...)
Affinity DataIC50: 80nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 91nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 94nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657687(N-[1-(5-{2-[(butylamino)methyl]phenyl}thiophen-2-y...)
Affinity DataIC50: 98nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657690(6,7-dimethoxy-N-{1-[5-(2-{[(2-methoxyethyl)amino]m...)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657341(6,7-dimethoxy-2-methyl-N-[(1R)-1-(naphthalen-1-yl)...)
Affinity DataIC50: 130nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 140nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 150nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657512(N-[(1R)-1-(3-bromophenyl)ethyl]-6,7-dimethoxy-2-me...)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657609(N-[1-(5-{2-[(diethylamino)methyl]phenyl}thiophen-2...)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 180nMAssay Description:Inhibition of SOS1 in human K562 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 190nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 190nMAssay Description:Inhibition of SOS1 in human MOLM-13 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657680(N-[1-(5-{2-[1-aminoethyl]phenyl}thiophen-2-yl)ethy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 200nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657681(N-[1-(5-{2-[1-aminoethyl]phenyl}thiophen-2-yl)ethy...)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of SOS1 in human K562 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657565([2-(5-{1-[(6,7-dimethoxy-2-methylquinazolin-4-yl)a...)
Affinity DataIC50: 280nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 320nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 360nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50: 400nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM657774(N-[1-{5-[2-(2-aminopropan-2-yl)phenyl]thiophen-2-y...)
Affinity DataIC50: 400nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657540(US20240083857, Example 219 | N-{1-[5-(6,7-dihydro-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 410nMAssay Description:Inhibition of SOS1 in human HeLa cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-LIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 410nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657643(N-[1-(5-{2-[(3-fluoroazetidin-1-yl)methyl]phenyl}t...)
Affinity DataIC50: 410nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657540(US20240083857, Example 219 | N-{1-[5-(6,7-dihydro-...)
Affinity DataIC50: 450nMAssay Description:Inhibition of SOS1 in human MOLM-13 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataKd:  450nMAssay Description:Binding affinity to N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657686(N-[1-(5-{2-[(benzylamino)methyl]phenyl}thiophen-2-...)
Affinity DataIC50: 470nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657663(N-{(1R)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl}-6,7-d...)
Affinity DataIC50: 470nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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