Compile Data Set for Download or QSAR
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Report error Found 102 Enz. Inhib. hit(s) with all data for entry = 50009588
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  6nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  6nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530252(CHEMBL4475081)
Affinity DataIC50:  7nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530252(CHEMBL4475081)
Affinity DataIC50:  7nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530255(CHEMBL4452417 | US10975080, Example 70)
Affinity DataIC50:  8nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530255(CHEMBL4452417 | US10975080, Example 70)
Affinity DataIC50:  8nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)
Affinity DataIC50:  12nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)
Affinity DataIC50:  12nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530250(CHEMBL4436233 | US10975080, Example 32)
Affinity DataIC50:  22nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530250(CHEMBL4436233 | US10975080, Example 32)
Affinity DataIC50:  22nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530257(CHEMBL4570587 | US10975080, Example 84)
Affinity DataIC50:  27nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530257(CHEMBL4570587 | US10975080, Example 84)
Affinity DataIC50:  27nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)
Affinity DataIC50:  28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530244(CHEMBL4461938)
Affinity DataIC50:  28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530249(CHEMBL4455446 | US10975080, Example 14)
Affinity DataIC50:  28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530244(CHEMBL4461938)
Affinity DataIC50:  28nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530256(CHEMBL4437876)
Affinity DataIC50:  30nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530256(CHEMBL4437876)
Affinity DataIC50:  30nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530256(CHEMBL4437876)
Affinity DataIC50:  31nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  31nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530256(CHEMBL4437876)
Affinity DataIC50:  31nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530254(CHEMBL4475043)
Affinity DataIC50:  31nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530253(CHEMBL4539178)
Affinity DataIC50:  32nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530253(CHEMBL4539178)
Affinity DataIC50:  32nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530245(CHEMBL4539145 | US10975080, Example 15)
Affinity DataIC50:  34nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530245(CHEMBL4539145 | US10975080, Example 15)
Affinity DataIC50:  34nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530251(CHEMBL4439006 | US10975080, Example 75)
Affinity DataIC50:  36nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530251(CHEMBL4439006 | US10975080, Example 75)
Affinity DataIC50:  36nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530251(CHEMBL4439006 | US10975080, Example 75)
Affinity DataIC50:  36nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530251(CHEMBL4439006 | US10975080, Example 75)
Affinity DataIC50:  36nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  37nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  37nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  38nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  38nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530252(CHEMBL4475081)
Affinity DataIC50:  39nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530252(CHEMBL4475081)
Affinity DataIC50:  39nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50:  50nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530247(CHEMBL4459445 | US10975080, Example 20)
Affinity DataIC50:  50nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530250(CHEMBL4436233 | US10975080, Example 32)
Affinity DataIC50:  55nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530250(CHEMBL4436233 | US10975080, Example 32)
Affinity DataIC50:  55nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530240(CHEMBL4469071)
Affinity DataIC50:  67nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530240(CHEMBL4469071)
Affinity DataIC50:  67nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  70nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  70nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530244(CHEMBL4461938)
Affinity DataIC50:  93nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530244(CHEMBL4461938)
Affinity DataIC50:  93nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530257(CHEMBL4570587 | US10975080, Example 84)
Affinity DataIC50:  96nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530257(CHEMBL4570587 | US10975080, Example 84)
Affinity DataIC50:  96nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

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