Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50007333 Sort by
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50038879(JTP-4819 | CHEMBL79993 | (S)-2-(2-Formyl-pyrrolidi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50199522((+-)-HA | (1R,9R)-1-Amino-13-eth-(E)-ylidene-11-me...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataIC50: 800nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50292332(CHEMBL1270849 | 2,3,9,10-tetramethoxy-5,6-dihydro-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508729(CHEMBL4548293)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 4.23E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508729(CHEMBL4548293)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508728(CHEMBL4590539)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508730(Oxyberberine)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508731(CHEMBL4585711)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508728(CHEMBL4590539)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508726(CHEBI:7714 | NSC-251534 | OBAMEGINE)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50292332(CHEMBL1270849 | 2,3,9,10-tetramethoxy-5,6-dihydro-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508731(CHEMBL4585711)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508730(Oxyberberine)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508726(CHEBI:7714 | NSC-251534 | OBAMEGINE)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50199522((+-)-HA | (1R,9R)-1-Amino-13-eth-(E)-ylidene-11-me...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508728(CHEMBL4590539)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 1.42E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50203126(Berberinechloride | 9,10-Dimethoxy-5,6-dihydro-[1,...)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of POP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508726(CHEBI:7714 | NSC-251534 | OBAMEGINE)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508730(Oxyberberine)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508731(CHEMBL4585711)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50292332(CHEMBL1270849 | 2,3,9,10-tetramethoxy-5,6-dihydro-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataKi:  6.41E+3nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCholinesterase(Human)
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataKi:  3.97E+4nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-substrate-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed