Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50010309
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:Inhibition of HIF-1alpha (786 to 826 residues) (unknown origin)/p300 (unknown origin) protein-protein interaction by ITCMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of HIF-1alpha/p300 protein-protein interaction in human cells after 2 hrs by immunoprecipitation assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human fluorescein-labeled HIF-1alpha (786 to 826 residues)/ human GST-fused p300 CH1 domain (323 to 423 residues) protein-protein inter...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HIF-1 dimerization in HEK293 cells after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human fluorescein-labeled HIF-1alpha (786 to 826 residues)/ human GST-fused p300 CH1 domain (323 to 423 residues) protein-protein inter...More data for this Ligand-Target Pair
Affinity DataIC50: 9.19E+3nMAssay Description:Binding affinity to human p300 CH1 domain (330 to 420 residues) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Binding affinity to human p300 CH1 domain (330 to 420 residues) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of fluorescein-labeled HIF-1alpha (786 to 826 residues) (unknown origin)/GST-fused p300 CH1 domain (323 to 423 residues) (unknown origin) ...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interaction by fluorescence anisotropyMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interaction by fluorescence anisotropyMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.76E+5nMAssay Description:Inhibition of fluorescein-labeled HIF-1alpha (786 to 826 residues) (unknown origin)/GST-fused p300 CH1 domain (323 to 423 residues) (unknown origin) ...More data for this Ligand-Target Pair
Affinity DataKd: 690nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
Affinity DataKd: 750nMAssay Description:Binding affinity to human GST-fused p300 CH1 domain (323 to 423 residues) under hypoxic condition by SPR assayMore data for this Ligand-Target Pair
Affinity DataKd: 530nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 45nMAssay Description:Binding affinity to p300 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
Affinity DataKd: 124nMAssay Description:Binding affinity to His-tagged HIF-1alpha (1 to 350 residues) (unknown origin) PAS B domain expressed in Escherichia coli BL21(DE3) by ITCMore data for this Ligand-Target Pair
Affinity DataKd: 6.74E+3nMAssay Description:Binding affinity to p300 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Affinity DataKd: 3.00E+4nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.62E+3nMAssay Description:Binding affinity to human GST-fused p300 CH1 domain (323 to 423 residues) under hypoxic condition by SPR assayMore data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to p300 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
