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Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50007606
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataKi:  20nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  0.0290nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged EGFR using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of EGFR (unknown origin) assessed as reduction of phosphorylation of polyglutamic acid/tyrosine incubated for 10 mins by beta scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant His-tagged HER2 (catalytic domain 691 to 1255 residues) using polyglutamic acid/tyrosine as substrate by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510887(CHEMBL4547332)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM12255(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50437353(CHEMBL2408045)
Affinity DataIC50:  3nMAssay Description:Inhibition of human HER2 expressed in baculovirus/Sf21 system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  4nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50437353(CHEMBL2408045)
Affinity DataIC50:  4nMAssay Description:Inhibition of human EFGR expressed in baculovirus/Sf21 system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-3(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50437353(CHEMBL2408045)
Affinity DataIC50:  4nMAssay Description:Inhibition of human HER3 expressed in baculovirus/Sf21 system by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R/T790M mutant (catalytic domain 695 to end) expressed in baculovirus-infected Sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM6198(AZD0530 analogue 35 | M475271 | Methoxy Aniline 7 ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant Src expressed in baculovirus infected Sf9 insect cells assessed as reduction in phosphorylation of polyglutamic acid/...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGFR (unknown origin) assessed as reduction of phosphorylation of Crk incubated for 10 mins in ice with gamma-ATP followed by incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510888(CHEMBL4544826)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant GST-tagged VEGFR2 (catalytic domain 805 to 1356 residues) expressed in Sf9 insect cells incubated for 45 mins by Kina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  6nMAssay Description:Inhibition of EGFR (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50205268(ARRY-334543 | ARRY-543 | ASLAN-001 | Varlitinib)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant full length EGFR using polyglutamic acid/tyrosine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM31340(2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant GST-tagged HER2 (unknown origin) (catalytic domain 675 to 1225) residues expressed in baculovirus-infected Sf9 cells assess...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510885(CHEMBL3109738 | JNJ-26483327)
Affinity DataIC50: <10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R/T790M mutant using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR (unknown origin) expressed in baculovirus system assessed as reduction in phosphorylation of Peptide A incubated for 10 mins by sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetVascular endothelial growth factor receptor 3(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510885(CHEMBL3109738 | JNJ-26483327)
Affinity DataIC50:  11nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510885(CHEMBL3109738 | JNJ-26483327)
Affinity DataIC50:  11nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510885(CHEMBL3109738 | JNJ-26483327)
Affinity DataIC50:  11nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 (unknown origin) using pEY as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PAK 4(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50237832(CHEMBL1198335)
Affinity DataIC50:  15nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as reduction in histone phosphorylation incubated for 1 hr at 4 degC by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2 (unknown origin) assessed as reduction of phosphorylation of polyglutamic acid/tyrosine incubated for 10 mins by beta scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  26nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetAurora kinase B(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50466805(CHEMBL4282530)
Affinity DataIC50:  41nMAssay Description:Inhibition of Aurora B in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  46nMAssay Description:Inhibition of HER2 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PAK 1(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50237832(CHEMBL1198335)
Affinity DataIC50:  48nMAssay Description:Inhibition of PAK1 (unknown origin) assessed as reduction in histone phosphorylation incubated for 1 hr at 4 degC by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf21 insect cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50466805(CHEMBL4282530)
Affinity DataIC50:  60nMAssay Description:Inhibition of Aurora A in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510887(CHEMBL4547332)
Affinity DataIC50:  103nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50:  105nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50:  105nMAssay Description:Inhibition of human recombinant GST-tagged EGFR (catalytic domain 695 to end) expressed in baculovirus-infected Sf9 cells assessed as reduction in ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM14210(4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-mo...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant His6-tagged Aurora A expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM14210(4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-mo...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant His6-tagged Aurora B expressed in baculovirus using Biotinyl-Ahx-tetra (LRRWSLG) as substrate incubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  220nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in cell proliferation incubated for 72 hrs by Coulter counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  300nMAssay Description:Inhibition of EGFR in human DIFI cells assessed as reduction in cell proliferation incubated for 72 hrs by Coulter counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  400nMAssay Description:Inhibition of EGFR in human DU145 cells assessed as reduction in cell proliferation incubated for 72 hrs by Coulter counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  680nMAssay Description:Inhibition of EGFR in human MDA-MB-468 cells assessed as reduction in cell proliferation incubated for 72 hrs by Coulter counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  950nMAssay Description:Inhibition of EGFR in human ME180 cells assessed as reduction in cell proliferation incubated for 72 hrs by Coulter counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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