BindingDB PrimarySearch_ki

Found 43 Enz. Inhib. hit(s) with all data for entry = 50008703

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 8.70nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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3D Structure (crystal)

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521389(CHEMBL4468399)

IC50: 13nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521392(CHEMBL4515145)

IC50: 15nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521395(CHEMBL4564974)

IC50: 19nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521398(CHEMBL4450464)

IC50: 20nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521396(CHEMBL4436823)

IC50: 24nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521388(CHEMBL4544864)

IC50: 49nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50041010(BAY-736691 | CHEMBL1513993)

IC50: 50nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521397(CHEMBL4465401)

IC50: 88nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521394(CHEMBL4457086)

IC50: 91nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521393(CHEMBL4445082)

IC50: 100nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521387(CHEMBL4435082)

IC50: 103nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521386(CHEMBL4543521)

IC50: 112nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521391(CHEMBL4537603)

IC50: 227nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521390(CHEMBL4453141)

IC50: 594nMAssay Description:Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521394(CHEMBL4457086)

IC50: 700nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521395(CHEMBL4564974)

IC50: 1.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521389(CHEMBL4468399)

IC50: 1.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 1.30E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521386(CHEMBL4543521)

IC50: 1.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521390(CHEMBL4453141)

IC50: 1.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521391(CHEMBL4537603)

IC50: 1.70E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521398(CHEMBL4450464)

IC50: 1.80E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521396(CHEMBL4436823)

IC50: 2.00E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521397(CHEMBL4465401)

IC50: 2.20E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521387(CHEMBL4435082)

IC50: 2.40E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 4.01E+3nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 4.83E+3nMAssay Description:Inhibition of PDE7A1 catalytic domain (130 to 482 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: 7.31E+3nMAssay Description:Inhibition of human PDE10A catalytic domain (449 to 770 residues) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521393(CHEMBL4445082)

IC50: 7.80E+3nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) using [3H]cAMP as substrate after 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using [14C]-dextromethorphan as substrate preincubated for 2 mins in presence of NADPH followed by sub...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE2A catalytic domain (580 to 919 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting...More data for this Ligand-Target Pair

PDB Reactome pathway
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521392(CHEMBL4515145)

IC50: 1.00E+4nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using [14C]-naproxen as substrate preincubated for 2 mins in presence of NADPH followed by substrate a...More data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using [14C]-erythromycin as substrate preincubated for 2 mins in presence of NADPH followed by substra...More data for this Ligand-Target Pair

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Cytochrome P450 1A2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using [14C]-ethoxyresorufin as substrate preincubated for 2 mins in presence of NADPH followed by subs...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE1C (2 to 634 residues) expressed in baculovirus infected Sf9 cells using 3H-cGMP as substrat...More data for this Ligand-Target Pair

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521388(CHEMBL4544864)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE8A1 catalytic domain (480 to 820 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation count...More data for this Ligand-Target Pair

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Cytochrome P450 2B6(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes in presence of NADPHMore data for this Ligand-Target Pair

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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE3A catalytic domain (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate after 15 mins by liquid scintillation countin...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

PNG

BDBM50521385(CHEMBL4580164)

IC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair

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Filter my 43 hits

Targets 16▿
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 15
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 14
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- Potassium voltage-gated channel subfamily H member 2 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 1
- Cytochrome P450 1A2 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2D6 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- Cytochrome P450 2B6 1
- Cytochrome P450 3A4 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- J Med Chem 62: 4218-4224 (2019) 43
Institutions 1▿
- Sun Yat-Sen University 43
Affinity: 8.7 to 3.0E+4 nM▿
- IC50 43
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 2