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Found 13 Enz. Inhib. hit(s) with all data for entry = 50007571
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataKi:  37nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataKi:  389nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510627(CHEMBL4587609)
Affinity DataKi:  407nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510629(CHEMBL4539697)
Affinity DataKi:  692nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  132nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510627(CHEMBL4587609)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50013224(CHEMBL351355 | Pyrrolidin-3-yl-acetic acid | Pyrro...)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510629(CHEMBL4539697)
Affinity DataIC50:  4.79E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  7.24E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataIC50:  5.37E+4nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510630(CHEMBL4586784)
Affinity DataIC50:  6.76E+4nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataKd:  27nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed