Compile Data Set for Download or QSAR
Report error Found 128 Enz. Inhib. hit(s) with all data for entry = 50035701
LigandChemical structure of BindingDB Monomer ID 50227014BDBM50227014(CHEMBL432927)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022424BDBM50022424(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226988BDBM50226988(CHEMBL81536)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022499BDBM50022499(7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226984BDBM50226984(CHEMBL77679)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022415BDBM50022415(6-chloro-(4'S)-spiro[3,4-dihydro-2H-chromene-4,5'-...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226987BDBM50226987(CHEMBL78819)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022480BDBM50022480(c6-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226983BDBM50226983(CHEMBL79461)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022470BDBM50022470(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226991BDBM50226991(CHEMBL419474)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50226985BDBM50226985(CHEMBL309288)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16312BDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022396BDBM50022396(7-trifluoromethylspiro[3,4-dihydro-2H-chromene-4,4...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022398BDBM50022398(6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,5'-[...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022407BDBM50022407(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022393BDBM50022393(5,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022422BDBM50022422(6-methylsulfanylspiro[3,4-dihydro-2H-chromene-4,4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022423BDBM50022423(7'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022391BDBM50022391(6'-bromospiro[tetrahydro-1H-imidazole-4,4'-(3',4'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022498BDBM50022498(6-Chloro-3,4-dihydro-2H-benzo[h]chromene-4-carboxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022434BDBM50022434(spiro[tetrahydro-1H-imidazole-4,4'-(3',4'-dihydro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022492BDBM50022492(8-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16312BDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022436BDBM50022436(spiro[tetrahydro-1H-imidazole-4,1'-(2',3'-dihydro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022401BDBM50022401(8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022459BDBM50022459(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022473BDBM50022473(6-bromospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahy...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022418BDBM50022418((1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022458BDBM50022458(6'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022471BDBM50022471(5,7,8-trimethylspiro[3,4-dihydro-2H-chromene-4,4'-...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022435BDBM50022435(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50022494BDBM50022494(2-(2,5-Dioxo-imidazolidin-4-yl)-benzo[de]isoquinol...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022433BDBM50022433(6,7-Dichloro-thiochroman-4-carboxylic acid | CHEMB...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022487BDBM50022487(spiro[tetrahydro-1H-imidazole-4,4'-(3',4'-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022425BDBM50022425(2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolid...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022397BDBM50022397(8-chloro-6-phenylspiro[3,4-dihydro-2H-chromene-4,4...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022418BDBM50022418((1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022410BDBM50022410(6-Chloro-8-methyl-chroman-4-carboxylic acid | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022501BDBM50022501(7',8'-dihydro-2H,5H,6'H-spiro[imidazolidine-4,5'-q...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022441BDBM50022441(6'-methoxyspiro[tetrahydro-1H-imidazole-4,4'-(3',4...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022438BDBM50022438(spiro[1,2,3,4-tetrahydronaphthalene-1,5'-(tetrahyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022437BDBM50022437(5'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022490BDBM50022490(cspiro[2,3-dihydro-1H-benzo[f]chromene-1,4'-(tetra...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 16415BDBM16415((1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50022426BDBM50022426(6'-fluoro-(4'R)-spiro[1H,2H-imidazole-4,4'-(3',4'-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022444BDBM50022444(2',3'-dihydro-2H,5H-spiro[imidazolidine-4,4'-thioc...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022447BDBM50022447(6-phenoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022440BDBM50022440(spiro[tetrahydro-1H-imidazole-4,5'-(6',7'-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50022461BDBM50022461(6'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
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