Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 128 Enz. Inhib. hit(s) with all data for entry = 50035701
LigandPNGBDBM50022499(7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226987(CHEMBL78819)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226988(CHEMBL81536)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022424(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50227014(CHEMBL432927)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226983(CHEMBL79461)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226991(CHEMBL419474)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226985(CHEMBL309288)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022470(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022480(CHEMBL78963 | c6-chlorospiro[3,4-dihydro-2H-chrome...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022415(6-chloro-(4'S)-spiro[3,4-dihydro-2H-chromene-4,5'-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50226984(CHEMBL77679)
Affinity DataIC50: <100nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity towards human placenta aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50022418((1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022459(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022423(7'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022391(6'-bromospiro[tetrahydro-1H-imidazole-4,4'-(3',4'-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022422(6-methylsulfanylspiro[3,4-dihydro-2H-chromene-4,4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022398((+)-6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022407(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022473(6-bromospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahy...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022435(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022471(5,7,8-trimethylspiro[3,4-dihydro-2H-chromene-4,4'-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022436(CHEMBL312392 | spiro[tetrahydro-1H-imidazole-4,1'-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022393(5,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50022492(8-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022498(6-Chloro-3,4-dihydro-2H-benzo[h]chromene-4-carboxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022401(8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022434(CHEMBL81601 | spiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022458(6'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022396(7-trifluoromethylspiro[3,4-dihydro-2H-chromene-4,4...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldo-keto reductase family 1 member B1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50022494(2-(2,5-Dioxo-imidazolidin-4-yl)-benzo[de]isoquinol...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibitory activity towards partially purified human placenta aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022501(7',8'-dihydro-2H,5H,6'H-spiro[imidazolidine-4,5'-q...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022490(CHEMBL81353 | cspiro[2,3-dihydro-1H-benzo[f]chrome...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022487(CHEMBL79015 | spiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022484(6,8-Dichloro-chroman-4-carboxylic acid | CHEMBL811...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022456(CHEMBL81718 | c5'-methoxyspiro[tetrahydro-1H-imida...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022461(6'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022453(6,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022449(2-Benzyl-2H-[1,2,4]triazine-3,5-dione | CHEMBL8197...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022444(2',3'-dihydro-2H,5H-spiro[imidazolidine-4,4'-thioc...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022447(6-phenoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022438(3,4-dihydro-2H,2'H,4'H-spiro[naphthalene-1,5'-[1,3...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022441(6'-methoxyspiro[tetrahydro-1H-imidazole-4,4'-(3',4...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022437(5'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022433(6,7-Dichloro-thiochroman-4-carboxylic acid | CHEMB...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022425(2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolid...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022406(6-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50022410(6-Chloro-8-methyl-chroman-4-carboxylic acid | CHEM...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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