Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50006720
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502721BDBM50502721(CHEMBL4435639 | US11440915, Example 9)
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502715BDBM50502715(CHEMBL4567728 | US11440915, Example 10)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50502709BDBM50502709(CHEMBL4538936 | US11440915, Example 8)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502714BDBM50502714(CHEMBL4470732 | US11440915, Example 7)
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502710BDBM50502710(CHEMBL4520800 | US11440915, Example 1)
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502719BDBM50502719(CHEMBL4475670 | US11440915, Example 2)
Affinity DataIC50: 16nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502713BDBM50502713(CHEMBL4468874 | US11440915, Example 6)
Affinity DataIC50: 23nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502711BDBM50502711(CHEMBL4515522 | US11440915, Example 3)
Affinity DataIC50: 25nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502712BDBM50502712(CHEMBL4439419 | US11440915, Example 5)
Affinity DataIC50: 26nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502722BDBM50502722(CHEMBL4522681 | US11440915, Example 14)
Affinity DataIC50: 27nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502720BDBM50502720(CHEMBL4474921 | US11440915, Example 4)
Affinity DataIC50: 31nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502716BDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataIC50: 39nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502717BDBM50502717(CHEMBL4461898 | US11440915, Example 13)
Affinity DataIC50: 44nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502718BDBM50502718(CHEMBL4464675 | US11440915, Example 12)
Affinity DataIC50: 49nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed